Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity
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Monoaminergic and Histaminergic Strategies and Treatments in Brain DiseasesAntidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophyStructure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicityDihydroxybenzoic acid isomers differentially dissociate soluble biotinyl-Aβ(1-42) oligomers.Novel therapeutic approaches in multiple system atrophyThe many faces of α-synuclein: from structure and toxicity to therapeutic target.Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.A multi-pathway perspective on protein aggregation: implications for control of the rate and extent of amyloid formation.Analysis of hippocampal gene expression profile of Alzheimer's disease model rats using genome chip bioinformaticsBenzbromarone, Quercetin, and Folic Acid Inhibit Amylin AggregationComparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formationInduction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's diseaseEntacapone is an Antioxidant More Potent than Vitamin C and Vitamin E for Scavenging of Hypochlorous Acid and Peroxynitrite, and the Inhibition of Oxidative Stress-Induced Cell Death.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils.Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection.Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease.Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Monoamine oxidase and α-synuclein as targets in Parkinson's disease therapy.Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system.NeuroAiD® (MLC601) and amyloid precursor protein processing.Implications of peptide assemblies in amyloid diseases.Amyloid single-cell cytotoxicity assays by nanomotion detection.Tau-derived-hexapeptide 306VQIVYK311 aggregation inhibitors: nitrocatechol moiety as a pharmacophore in drug designThe Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists.From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease.Effects of antiparkinsonian agents on β-amyloid and α-synuclein oligomer formation in vitro.Detection, inhibition and disintegration of amyloid fibrils: the role of optical probes and macrocyclic receptors.Role of Quercetin Benefits in Neurodegeneration.Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer's disease.Amyloid aggregation of lysozyme: the synergy study of red wine polyphenols.Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition.
P2860
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P2860
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@ast
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@en
type
label
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@ast
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@en
prefLabel
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@ast
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@en
P2093
P2860
P50
P356
P1476
Entacapone and tolcapone, two ...... ainst amyloid-induced toxicity
@en
P2093
Guowei Yin
Katerina E Paleologou
Markus Zweckstetter
Saviana Di Giovanni
Simona Eleuteri
P2860
P304
14941-14954
P356
10.1074/JBC.M109.080390
P407
P577
2010-02-11T00:00:00Z