Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.
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Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulumAn antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.Probing the folding pathway of a consensus serpin using single tryptophan mutants.Well-Known and Less Well-Known Functions of Alpha-1 Antitrypsin. Its Role in Chronic Obstructive Pulmonary Disease and Other Disease Developments.α1-Antitrypsin deficiency.
P2860
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P2860
Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Altered native stability is th ...... sin mutants to polymerization.
@ast
Altered native stability is th ...... sin mutants to polymerization.
@en
type
label
Altered native stability is th ...... sin mutants to polymerization.
@ast
Altered native stability is th ...... sin mutants to polymerization.
@en
prefLabel
Altered native stability is th ...... sin mutants to polymerization.
@ast
Altered native stability is th ...... sin mutants to polymerization.
@en
P2093
P2860
P356
P1433
P1476
Altered native stability is th ...... sin mutants to polymerization.
@en
P2093
David A Lomas
Jennifer A Dickens
Sarah V Faull
P2860
P304
P356
10.1042/BJ20131650
P407
P577
2014-05-01T00:00:00Z