APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. - Wikidata - awgldk - TriplyDB

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

http://www.wikidata.org/entity/Q33842900

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Insights into APC/C: from cellular function to diseases and therapeutics Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis Regulation of Bim in Health and Disease The role of aberrant proteolysis in lymphomagenesis The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis.Targeting Cdc20 as a novel cancer therapeutic strategy.Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma.A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.CDC20 maintains tumor initiating cells.Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells.The Bcl-2 family: structures, interactions and targets for drug discovery.Latent Pathways Identification by Microarray Expression Profiles in Thyroid-Associated Ophthalmopathy Patients.Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division Cycle 20 (Cdc20) in Pancreatic Cancer Cells.AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers.Mcl-1 dynamics influence mitotic slippage and death in mitosis.Identification of the APC/C co-factor FZR1 as a novel therapeutic target for multiple myeloma.A mitosis-sensing caspase activation platform? New insights into the PIDDosome.Paclitaxel-induced aberrant mitosis and mitotic slippage efficiently lead to proliferative death irrespective of canonical apoptosis and p53.An Inhibitor of PIDDosome Formation.Stop competing, start talking!Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.Cdc20 overexpression is involved in temozolomide-resistant glioma cells with epithelial-mesenchymal transition.CDC20siRNA and paclitaxel co-loaded nanometric liposomes of a nipecotic acid-derived cationic amphiphile inhibit xenografted neuroblastoma.Identification of differentially expressed genes in human breast cancer cells induced by 4-hydroxyltamoxifen and elucidation of their pathophysiological relevance and mechanisms.Cell division cycle 20 promotes cell proliferation and invasion and inhibits apoptosis in osteosarcoma cells.Perturbing mitosis for anti-cancer therapy: is cell death the only answer?Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.

P2860

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P2860

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

http://www.wikidata.org/entity/Q33842900

description

2014 nî lūn-bûn

@nan

2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

@en

type

label

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

@en

prefLabel

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

@en

P1433

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P932

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P356

J.DEVCEL.2014.04.022

P1433

Developmental Cell

P1476

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction.

@en

P2093

Anthony Letai

http://www.w3.org/2001/XMLSchema#string

Guoan Chen

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Inuzuka

http://www.w3.org/2001/XMLSchema#string

Jia Liu

http://www.w3.org/2001/XMLSchema#string

Jie Yang

http://www.w3.org/2001/XMLSchema#string

Jing Deng

http://www.w3.org/2001/XMLSchema#string

Lixin Wan

http://www.w3.org/2001/XMLSchema#string

Marc W Kirschner

http://www.w3.org/2001/XMLSchema#string

Mingjia Tan

http://www.w3.org/2001/XMLSchema#string

Shavali Shaik

http://www.w3.org/2001/XMLSchema#string

P2860

Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage

RACK1 and CIS mediate the degradation of BimEL in cancer cells

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.

BAX activation is initiated at a novel interaction site

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

P304

377-391

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P31

scholarly article

P356

10.1016/J.DEVCEL.2014.04.022

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P407

P433

4

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P478

29

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P50

Marcos Malumbres

P577

2014-05-01T00:00:00Z

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P5875

262697570

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P698

24871945

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P921

protein ubiquitination

P932

4081014

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