Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.
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APLP2 Regulates Refractive Error and Myopia Development in Mice and HumansGenetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traitsFive years of GWAS discoveryUnderstanding rare and common diseases in the context of human evolutionThe evolutionary genetics of the genes underlying phenotypic associations for loblolly pine (Pinus taeda, Pinaceae)The genetic architecture of type 2 diabetesMultilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies.Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples.The impact of population demography and selection on the genetic architecture of complex traits.Association mapping of insecticide resistance in wild Anopheles gambiae populations: major variants identified in a low-linkage disequilbrium genome.An evolutionary framework for association testing in resequencing studies.Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectationsSynthetic associations created by rare variants do not explain most GWAS results.Evolution in health and medicine Sackler colloquium: Evolutionary perspectives on health and medicine.GWAS to Sequencing: Divergence in Study Design and AnalysisLarge-scale genomics unveils the genetic architecture of psychiatric disordersHaplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Conditions for the validity of SNP-based heritability estimation.Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses.Population genetic differentiation of height and body mass index across Europe.An evolutionary perspective on epistasis and the missing heritabilityPopulation genetic simulations of complex phenotypes with implications for rare variant association testsA genome-wide comparison of the functional properties of rare and common genetic variants in humansEvolutionary behavioral genetics.Assumptions and properties of limiting pathway models for analysis of epistasis in complex traitsGenome partitioning of genetic variation for complex traits using common SNPsDistribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants.Estimating proportions of explained variance: a comparison of whole genome subsets.The evolutionarily stable distribution of fitness effectsQuantifying the variation in the effective population size within a genome.Quantitative genetics in the genomics era.Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.Human genomic disease variants: a neutral evolutionary explanation.A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.Explaining additional genetic variation in complex traitsDeep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.The genetics of blood pressure and hypertension: the role of rare variation.
P2860
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P2860
Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Evolution in health and medici ...... nome-wide association studies.
@ast
Evolution in health and medici ...... nome-wide association studies.
@en
type
label
Evolution in health and medici ...... nome-wide association studies.
@ast
Evolution in health and medici ...... nome-wide association studies.
@en
prefLabel
Evolution in health and medici ...... nome-wide association studies.
@ast
Evolution in health and medici ...... nome-wide association studies.
@en
P2860
P356
P1476
Evolution in health and medici ...... nome-wide association studies.
@en
P2860
P304
P356
10.1073/PNAS.0906182107
P407
P478
107 Suppl 1
P577
2010-01-19T00:00:00Z