MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. - Wikidata - awgldk - TriplyDB

MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.

MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.

http://www.wikidata.org/entity/Q33844725

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Mediator kinase module and human tumorigenesis MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal leiomyoma with t(10;17)(q22;q21)Factors affecting the loss of MED12-mutated leiomyoma cells during in vitro growth Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.MED12 exon 2 mutations in phyllodes tumors of the breast Targeted next-generation sequencing of cancer genes identified frequent TP53 and ATRX mutations in leiomyosarcoma.Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution.History of uterine leiomyoma and risk of endometrial cancer in black women.The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases.Genetic heterogeneity in leiomyomas of deep soft tissue.Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma.Malignant mesenchymal tumors of the uterus - time to advocate a genetic classification.Molecular characteristics of uterine sarcomas.Molecular and clinical attributes of uterine leiomyomas.Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids.Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma.Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma.A rare coincidence of different types of driver mutations among uterine leiomyomas (UL).Uterine fibroids - what's new?Comparative systems genetics view of endometriosis and uterine leiomyoma: Two sides of the same coin?Subtype-Specific Tumor-Associated Fibroblasts Contribute to the Pathogenesis of Uterine Leiomyoma.Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease.Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors.Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients.The study of MED12 gene mutations in uterine leiomyomas from Iranian patients.Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma.The selected biomarker analysis in five types of uterine smooth muscle tumors.Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo.MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation.

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MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma.

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2014年の論文

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MED12 and HMGA2 mutations: two ...... leiomyoma and leiomyosarcoma.

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MODPATHOL.2013.243

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Modern Pathology

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MED12 and HMGA2 mutations: two ...... leiomyoma and leiomyosarcoma.

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Beihua Kong

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Elizabeth Bertsch

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Jian-Jun Wei

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Khush Mittal

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Margarita Espona-Fiedler

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Qing Zhang

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Stacy Druschitz

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Wenan Qiang

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Yu Liu

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P2860

Alport syndrome and diffuse leiomyomatosis. Clinical aspects, pathology, molecular biology and extracellular matrix studies. A synthesis.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Leiomyomata: heritability and cytogenetic studies.

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

MED12 alterations in both human benign and malignant uterine soft tissue tumors.

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.

Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity.

The economic impact of uterine fibroids in the United States: a summary of published estimates.

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

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modpathol.2013.243

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