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Initial mutations direct alternative pathways of protein evolution

Initial mutations direct alternative pathways of protein evolution

http://www.wikidata.org/entity/Q33847781

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Stability-mediated epistasis constrains the evolution of an influenza protein Quantifying the adaptive potential of an antibiotic resistance enzyme The genetic code constrains yet facilitates Darwinian evolution Replaying the tape of life in the twenty-first century The causes of epistasis Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution Costs of antibiotic resistance - separating trait effects and selective effects Environmental changes bridge evolutionary valleys Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories Coordinated Evolution of Influenza A Surface Proteins Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization Reverse evolution leads to genotypic incompatibility despite functional and active site convergence The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment Contingency and entrenchment in protein evolution under purifying selection Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas Convergent adaptation to dangerous prey proceeds through the same first-step mutation in the garter snake Thamnophis sirtalis.Protein structural robustness to mutations: an in silico investigation.Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes.Mistranslation can enhance fitness through purging of deleterious mutations.Loss of Heterozygosity Drives Adaptation in Hybrid Yeast Causes of molecular convergence and parallelism in protein evolution.Rethinking Hardy-Weinberg and genetic drift in undergraduate biology.Intramolecular epistasis and the evolution of a new enzymatic function The effect of bacterial recombination on adaptation on fitness landscapes with limited peak accessibility Multivariate phenotypic divergence due to the fixation of beneficial mutations in experimentally evolved lineages of a filamentous fungus.Replaying the tape of life: quantification of the predictability of evolution.The cost of antibiotic resistance depends on evolutionary history in Escherichia coli.Mechanisms of protein sequence divergence and incompatibility.Properties of selected mutations and genotypic landscapes under Fisher's geometric model.Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics.Epistasis among adaptive mutations in deer mouse hemoglobin.Toward a systems biology perspective on enzyme evolution.Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Breaking evolutionary constraint with a tradeoff ratchet.

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P2860

Initial mutations direct alternative pathways of protein evolution

http://www.wikidata.org/entity/Q33847781

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Initial mutations direct alternative pathways of protein evolution

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Initial mutations direct alternative pathways of protein evolution

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type

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Initial mutations direct alternative pathways of protein evolution

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Initial mutations direct alternative pathways of protein evolution

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Initial mutations direct alternative pathways of protein evolution

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Initial mutations direct alternative pathways of protein evolution

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JOURNAL.PGEN.1001321

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Initial mutations direct alternative pathways of protein evolution

@en

P2093

Alfons J M Debets

http://www.w3.org/2001/XMLSchema#string

Dan S Tawfik

http://www.w3.org/2001/XMLSchema#string

Eynat Dellus

http://www.w3.org/2001/XMLSchema#string

Florien A Gorter

http://www.w3.org/2001/XMLSchema#string

J Arjan G M de Visser

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Merijn L M Salverda

http://www.w3.org/2001/XMLSchema#string

Rolf F Hoekstra

http://www.w3.org/2001/XMLSchema#string

P2860

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation.

Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

Increased folding stability of TEM-1 beta-lactamase by in vitro selection

Rapid evolution of a protein in vitro by DNA shuffling

Parallel genotypic adaptation: when evolution repeats itself

Darwinian evolution can follow only very few mutational paths to fitter proteins

Statistics of protein library construction.

Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans

Intense neutral drifts yield robust and evolvable consensus proteins.

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e1001321

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10.1371/JOURNAL.PGEN.1001321

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3

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7

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John van der Oost

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2011-03-03T00:00:00Z

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50400195

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21408208

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P921

protein evolution

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3048372

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