Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.
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Human keratinocytes have two interconvertible modes of proliferation.Self-organized centripetal movement of corneal epithelium in the absence of external cues.Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population.NOTCH pathway inactivation promotes bladder cancer progressionCell competition: winning out by losing notchSwitching roles: the functional plasticity of adult tissue stem cells.Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.Deep insights: intravital imaging with two-photon microscopy.Dynamic heterogeneity as a strategy of stem cell self-renewalPredicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program.New insights into the unfolded protein response in stem cells.Mutation, clonal fitness and field change in epithelial carcinogenesis.Somatic mutation in cancer and normal cells.Adult stem cell lineage tracing and deep tissue imaging.Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch.A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity.HES5 silencing is an early and recurrent change in prostate tumourigenesis.Development and stem cells of the esophagus.Notch as a tumour suppressor.Evolution of Premalignant Disease.Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration.The Varied Roles of Notch in Cancer.Exact, time-independent estimation of clone size distributions in normal and mutated cells.Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.Spatial constraints govern competition of mutant clones in human epidermis.Constrained positive selection on cancer mutations in normal skin.Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking.Tissue Engineering Functional Gastrointestinal Regions: The Importance of Stem and Progenitor Cells.A Model for Adult Organ Resizing Demonstrates Stem Cell Scaling through a Tunable Commitment Rate.Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.Revealing age-related changes of adult hippocampal neurogenesis using mathematical models.Stem Cell Microenvironments and Beyond.Oesophageal Stem Cells and Cancer.A single dividing cell population with imbalanced fate drives oesophageal tumour growth.An evolutionary perspective on field cancerization.The developmental origin of brain tumours: a cellular and molecular framework.Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations
P2860
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P2860
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Differentiation imbalance in s ...... ortalization and field change.
@ast
Differentiation imbalance in s ...... ortalization and field change.
@en
type
label
Differentiation imbalance in s ...... ortalization and field change.
@ast
Differentiation imbalance in s ...... ortalization and field change.
@en
altLabel
Differentiation imbalance in s ...... mortalization and field change
@en
prefLabel
Differentiation imbalance in s ...... ortalization and field change.
@ast
Differentiation imbalance in s ...... ortalization and field change.
@en
P2860
P50
P356
P1433
P1476
Differentiation imbalance in s ...... mortalization and field change
@en
P2093
Agnieszka Wabik
P2860
P2888
P304
P356
10.1038/NCB2963
P577
2014-05-11T00:00:00Z
P6179
1008960303