Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
about
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunctionDeubiquitinating enzymes in cellular signaling and disease regulationCellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's diseaseRole of prostaglandins in neuroinflammatory and neurodegenerative diseasesROSics: chemistry and proteomics of cysteine modifications in redox biology.In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury.Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438)The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest.Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neuronsProtein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for hypoxic ischemic injuryS-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2.Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2.Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging.Identification of tyrosine nitration in UCH-L1 and GAPDH.Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
P2860
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P2860
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@ast
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@en
type
label
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@ast
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@en
prefLabel
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@ast
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@en
P2093
P2860
P356
P1476
Cyclopentenone prostaglandin-i ...... son disease-associated UCH-L1.
@en
P2093
Ravindra B Kodali
Roberto Di Maio
Steven H Graham
P2860
P304
P356
10.1073/PNAS.1002295107
P407
P577
2010-03-15T00:00:00Z