Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
about
Species-specific temperature sensitivity of TRPA1Permeation, regulation and control of expression of TRP channels by trace metal ionsStructure of thermally activated TRP channelsA pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.TRPV1 structures in distinct conformations reveal activation mechanismsSingle residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformationsExploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screeningTRPV channels and vascular functionTRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity.The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing.Eugenol and carvacrol excite first- and second-order trigeminal neurons and enhance their heat-evoked responses.High temperature sensitivity is intrinsic to voltage-gated potassium channels.Kinetic and energetic analysis of thermally activated TRPV1 channelsExome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome.Thermally active TRPV1 tonically drives central spontaneous glutamate release.Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8).Modular thermal sensors in temperature-gated transient receptor potential (TRP) channelsRole of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cationsModality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site.A molecular framework for temperature-dependent gating of ion channelsA combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activationCytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.Modulation of TRPA1 thermal sensitivity enables sensory discrimination in DrosophilaStructural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel.Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material.Heteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical responseTRPM8 Channel Activation Induced by Monoterpenoid Rotundifolone Underlies Mesenteric Artery RelaxationSelective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations.Responses of human sensory characteristics to 532 nm pulse laser stimuli.Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.Thermal nociception using a modified Hargreaves method in primates and humans.An external sodium ion binding site controls allosteric gating in TRPV1 channelsA TRPV4 channel C-terminal folding recognition domain critical for trafficking and function.Use Dependence of Heat Sensitivity of Vanilloid Receptor TRPV2.The role of allosteric coupling on thermal activation of thermo-TRP channels.Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channelsRational design and validation of a vanilloid-sensitive TRPV2 ion channelSpecies differences and molecular determinant of TRPA1 cold sensitivity.Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels.
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P2860
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@ast
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@en
type
label
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@ast
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@en
prefLabel
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@ast
Thermosensitive TRP channel pore turret is part of the temperature activation pathway.
@en
P2093
P2860
P356
P1476
Thermosensitive TRP channel pore turret is part of the temperature activation pathway
@en
P2093
KeWei Wang
Yuanyuan Cui
P2860
P304
P356
10.1073/PNAS.1000357107
P407
P50
P577
2010-03-29T00:00:00Z