Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.

Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.

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http://www.wikidata.org/entity/Q33860831
Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?The "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancerEssential role for centromeric factors following p53 loss and oncogenic transformationCentrosome amplification and the development of cancer.Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.The paradigm of mutant p53-expressing cancer stem cells and drug resistance.p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint.Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents.Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.
P2860

Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.

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http://www.wikidata.org/entity/Q33860831
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2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
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2000年論文
@zh-hk
2000年論文
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2000年論文
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2000年论文
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name
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@ast
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@en
type
label
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@ast
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@en
prefLabel
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@ast
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@en
P1433
P1476
P2093
P2888
P304
P31
P356
P407
P433
P478
P577
P5875
P6179
P698
P356
P1433
P1476
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
@en
P2093
P2888
P304
P31
P356
P407
P433
P478
P577
P5875
P6179
P698