Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer
about
Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubesCancer stem cells in small cell lung cancerPulmonary adenocarcinoma: a renewed entity in 2011Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cellsDNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cellsStem Cell Factor-Based Identification and Functional Properties of In Vitro-Selected Subpopulations of Malignant Mesothelioma Cells.Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal.SOX2 is required to maintain cancer stem cells in ovarian cancer.SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.Genomics of squamous cell lung cancerSOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancerSOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells.Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genesCEACAM1 promotes melanoma cell growth through Sox-2.Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients.EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.True 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugsSox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity.Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profilingIdentification of biological properties of intralymphatic tumor related to the development of lymph node metastasis in lung adenocarcinomaIncreased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease.Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer.Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.Roles of sex-determining region Y-box 2 in cell pluripotency and tumor-related signaling pathways.Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2.The chromosome 3q26 OncCassette: A multigenic driver of human cancer.The role of Sox genes in lung morphogenesis and cancer.Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing's sarcoma through the PI3K/Akt pathwaySox2 enhances the tumorigenicity and chemoresistance of cancer stem-like cells derived from gastric cancerMultiple pluripotent stem cell markers in human anaplastic thyroid cancer: the putative upstream role of SOX2.Enhanced therapeutic effect of an antiangiogenesis peptide on lung cancer in vivo combined with salmonella VNP20009 carrying a Sox2 shRNA constructProline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients' overall survival.Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses.Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cellsThe multiple roles for Sox2 in stem cell maintenance and tumorigenesis.Cervical cancer cells with positive Sox2 expression exhibit the properties of cancer stem cells.SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis.Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
P2860
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P2860
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Downregulation of transcriptio ...... and metastasis of lung cancer
@ast
Downregulation of transcriptio ...... and metastasis of lung cancer
@en
type
label
Downregulation of transcriptio ...... and metastasis of lung cancer
@ast
Downregulation of transcriptio ...... and metastasis of lung cancer
@en
prefLabel
Downregulation of transcriptio ...... and metastasis of lung cancer
@ast
Downregulation of transcriptio ...... and metastasis of lung cancer
@en
P2093
P2860
P356
P1476
Downregulation of transcriptio ...... and metastasis of lung cancer
@en
P2093
D Markowitz
R A Reisfeld
T S Chuang
P2860
P2888
P304
P356
10.1038/BJC.2011.94
P407
P577
2011-04-05T00:00:00Z
P5875
P6179
1000595705