Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions - Wikidata - awgldk - TriplyDB

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions

http://www.wikidata.org/entity/Q33863886

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The lysosomal sialic acid transporter sialin is required for normal CNS myelination A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration Node of Ranvier disruption as a cause of neurological diseases Glycosphingolipid-Protein Interaction in Signal Transduction Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti.Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms.Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice.Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis Oligodendrocyte development and myelin biogenesis: parsing out the roles of glycosphingolipids Brain gangliosides in axon-myelin stability and axon regeneration.Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth.Multi-system disorders of glycosphingolipid and ganglioside metabolism Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.Myelin-associated glycoprotein and its axonal receptors Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons.Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis.Genetic defects in the human glycome.Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function.GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.Aging and gastrointestinal neuromuscular function: insights from within and outside the gut.Molecular mechanisms of pathogenesis in a glycosphingolipid and a glycoprotein storage disease Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons.Ganglioside biochemistry Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy.CD4 and CD8 T cells require different membrane gangliosides for activation.Sialylation regulates brain structure and function.Sphingolipid and ceramide homeostasis: potential therapeutic targets.It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation.Glycolipid and ganglioside metabolism imbalances in Huntington's disease.Gangliosides as apoptotic signals in ER stress response.Genetic diseases of sphingolipid metabolism: pathological mechanisms and therapeutic options.Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.In vivo metabolic labeling of sialoglycans in the mouse brain by using a liposome-assisted bioorthogonal reporter strategy Regulation of axonal development by plasma membrane gangliosides.

P2860

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P2860

Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions

http://www.wikidata.org/entity/Q33863886

description

2005 nî lūn-bûn

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2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2005 թվականի փետրվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Interruption of ganglioside sy ...... ltered axon-glial interactions

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Interruption of ganglioside sy ...... ltered axon-glial interactions

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type

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Interruption of ganglioside sy ...... ltered axon-glial interactions

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Interruption of ganglioside sy ...... ltered axon-glial interactions

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Interruption of ganglioside sy ...... ltered axon-glial interactions

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Interruption of ganglioside sy ...... ltered axon-glial interactions

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PNAS.0407785102

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Interruption of ganglioside sy ...... ltered axon-glial interactions

@en

P2093

Hiroki Mizukami

http://www.w3.org/2001/XMLSchema#string

Jeffrey L Dupree

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Jessica M Ellis

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Konrad Sandhoff

http://www.w3.org/2001/XMLSchema#string

Norbert Werth

http://www.w3.org/2001/XMLSchema#string

Richard L Proia

http://www.w3.org/2001/XMLSchema#string

Roger Sandhoff

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Rudolf Geyer

http://www.w3.org/2001/XMLSchema#string

Tadashi Yamashita

http://www.w3.org/2001/XMLSchema#string

Yun-Ping Wu

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P2860

The local differentiation of myelinated axons at nodes of Ranvier

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder

Sialic acid specificity of myelin-associated glycoprotein binding

Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

Paranodal junction formation and spermatogenesis require sulfoglycolipids

Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.

Gangliosides are neuronal ligands for myelin-associated glycoprotein.

Myelin galactolipids: mediators of axon-glial interactions?

Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration

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2725-2730

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10.1073/PNAS.0407785102

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102

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8022104

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15710896

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549464

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