FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway
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Novel drugs that target the metabolic reprogramming in renal cell cancerPosttranslational regulation of Akt in human cancermiR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stressGenomic Analysis as the First Step toward Personalized Treatment in Renal Cell CarcinomaSuppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.PI3K-Akt1 expression and its significance in liver tissues with chronic fluorosis.PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma.Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.A Phase Ib Study of BEZ235, a Dual Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR), in Patients With Advanced Renal Cell Carcinoma.BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response.AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1.HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A.A randomized phase 2 study of MK-2206 versus everolimus in refractory renal cell carcinoma.Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development.Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate.The PI3K Pathway in Human Disease.Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway.The role of RICTOR downstream of receptor tyrosine kinase in cancers.Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway.FoxO transcription factors in cancer metabolism.A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells.PI3K/AKT inhibitors in patients with refractory renal cell carcinoma: what have we learnt so far?Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease.BAP1 links metabolic regulation of ferroptosis to tumour suppressionPhosphorylation-Dependent Inhibition of Akt1
P2860
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P2860
FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@ast
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@en
type
label
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@ast
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@en
prefLabel
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@ast
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@en
P2093
P2860
P1433
P1476
FoxO transcription factors pro ...... bition of the PI3K-AKT pathway
@en
P2093
Dos D Sarbassov
Hai-Long Piao
P2860
P304
P356
10.1158/0008-5472.CAN-13-1729
P407
P50
P577
2014-01-21T00:00:00Z