Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.
about
Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screeningConstitutive activation of A(3) adenosine receptors by site-directed mutagenesisConstitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix sevenComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.Structure and regulation of opioid receptors.Homology modeling of opioid receptor-ligand complexes using experimental constraintsConformational changes of G protein-coupled receptors during their activation by agonist binding.Modeling and simulation of the human delta opioid receptor.Molecular Pharmacology of δ-Opioid Receptors.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffoldStructural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.Construction of a sequence motif characteristic of aminergic G protein-coupled receptorsStructural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin.Characteristics for a salt-bridge switch mutation of the alpha(1b) adrenergic receptor. Altered pharmacology and rescue of constitutive activity.Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure.Association between the A107V substitution in the δ-opioid receptors and ethanol drinking in mice selected for high and low analgesia.Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor.Molecular modeling study of the opioid receptor interactions with series of cyclic deltorphin analogues.Understanding the effects on constitutive activation and drug binding of a D130N mutation in the β2 adrenergic receptor via molecular dynamics simulation.Understanding the conformation transition in the activation pathway of β2 adrenergic receptor via a targeted molecular dynamics simulation.
P2860
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P2860
Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Constitutive activation of the ...... smembrane domains III and VII.
@ast
Constitutive activation of the ...... smembrane domains III and VII.
@en
type
label
Constitutive activation of the ...... smembrane domains III and VII.
@ast
Constitutive activation of the ...... smembrane domains III and VII.
@en
prefLabel
Constitutive activation of the ...... smembrane domains III and VII.
@ast
Constitutive activation of the ...... smembrane domains III and VII.
@en
P2093
P2860
P356
P1476
Constitutive activation of the ...... smembrane domains III and VII.
@en
P2093
P2860
P304
18574-18581
P356
10.1074/JBC.274.26.18574
P407
P577
1999-06-01T00:00:00Z