Role of single-stranded DNA binding activity of T antigen in simian virus 40 DNA replication
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Structure of the replicative helicase of the oncoprotein SV40 large tumour antigenStructure-Based Analysis of the Interaction between the Simian Virus 40 T-Antigen Origin Binding Domain and Single-Stranded DNAMutational analysis of simian virus 40 T-antigen primosome activities in viral DNA replication.Assembly of the replication initiation complex on SV40 origin DNA.Validation of BKV large T-antigen ATP-binding site as a target for drug discovery.Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationModel for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.Interactions required for binding of simian virus 40 T antigen to the viral origin and molecular modeling of initial assembly events.Nonspecific double-stranded DNA binding activity of simian virus 40 large T antigen is involved in melting and unwinding of the origin.Helicase Assays.Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation.Role of the hydrophilic channels of simian virus 40 T-antigen helicase in DNA replicationCharacterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase.Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling.Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism.Bypass of a protein barrier by a replicative DNA helicase.Protein encoded by HSV-1 stimulation-related gene 1 (HSRG1) interacts with and inhibits SV40 large T antigen.
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P2860
Role of single-stranded DNA binding activity of T antigen in simian virus 40 DNA replication
description
2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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type
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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Role of single-stranded DNA bi ...... imian virus 40 DNA replication
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P2860
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10.1128/JVI.75.6.2839-2847.2001
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2001-03-01T00:00:00Z