Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
about
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomasATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaksThe histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesisExome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaA small-cell lung cancer genome with complex signatures of tobacco exposureCovalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersInternational network of cancer genome projects.A decade of exploring the cancer epigenome - biological and translational implicationsDissecting the genomic complexity underlying medulloblastomaThe histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onsetInitial genome sequencing and analysis of multiple myelomaState of the science: an update on renal cell carcinomaHyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxiaRegulation of chromatin by histone modificationsEpigenetic modulators, modifiers and mediators in cancer aetiology and progressionTargeting EZH2 in cancerMutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomasCombating the epigenome: epigenetic drugs against non-Hodgkin's lymphomaMechanisms of epigenetic regulation of leukemia onset and progressionRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionMyeloid malignancies: mutations, models and managementThe oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylasesStructural basis for histone H3 Lys 27 demethylation by UTX/KDM6ASomatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma.Novel therapeutic strategies for multiple myelomaEZH2 in Bladder Cancer, a Promising Therapeutic TargetThe roles of chromatin-remodelers and epigenetic modifiers in kidney cancerJMJD3 as an epigenetic regulator in development and diseaseDeletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndromeHistone methylation: a dynamic mark in health, disease and inheritanceThe histone demethylase UTX enables RB-dependent cell fate controlThe genetic landscape of the childhood cancer medulloblastomaHistone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilizationFemale bias in Rhox6 and 9 regulation by the histone demethylase KDM6ATet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformationJumonji modulates polycomb activity and self-renewal versus differentiation of stem cellsTen-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
P2860
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P2860
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@ast
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@en
type
label
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@ast
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@en
prefLabel
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@ast
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@en
P2093
P2860
P50
P356
P1433
P1476
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
@en
P2093
Aaron Massie
Adam Butler
Catherine Leroy
Chai Yin Kok
Chris Greenman
Claire Hardy
Dave Beare
David J McBride
David Jones
Erin Pleasance
P2860
P2888
P304
P356
10.1038/NG.349
P407
P50
P577
2009-03-29T00:00:00Z
P5875
P6179
1001520036