The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
about
Phyla- and Subtype-Selectivity of CgNa, a Na Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis GiganteaSodium channel molecular conformations and antiarrhythmic drug affinityFrom foe to friend: using animal toxins to investigate ion channel functionVoltage-gated sodium channel-associated proteins and alternative mechanisms of inactivation and blockResurgent current of voltage-gated Na(+) channelsA distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1aTargeting voltage sensors in sodium channels with spider toxins.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Ion channel voltage sensors: structure, function, and pathophysiology.The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.Neurotoxins and their binding areas on voltage-gated sodium channels.Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.Arthropod venoms: a vast arsenal of insecticidal neuropeptides.Voltage-gated sodium channel modulation by scorpion alpha-toxins.Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels.Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.Electrophysiological characteristics of a SCN5A voltage sensors mutation R1629Q associated with Brugada syndromeVoltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivationDirect evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movementsFunctional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensorsElucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels.Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linkerBiophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB.Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channelsSodium channel inactivation: molecular determinants and modulation.Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.The role of the putative inactivation lid in sodium channel gating current immobilizationMolecular action of lidocaine on the voltage sensors of sodium channelsCoupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements.A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels.Neutralization of gating charges in domain II of the sodium channel alpha subunit enhances voltage-sensor trapping by a beta-scorpion toxinTracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.Role of domain 4 in sodium channel slow inactivationImmobilizing the moving parts of voltage-gated ion channelsOpening the shaker K+ channel with hanatoxin.
P2860
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P2860
The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@ast
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@en
type
label
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@ast
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@en
prefLabel
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@ast
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@en
P2093
P2860
P1433
P1476
The Na channel voltage sensor ...... ged residues of domain IV, S4.
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(99)76929-8
P407
P577
1999-08-01T00:00:00Z