Identification of the potassium channel opener site on sulfonylurea receptors.
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Synthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structureSulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridgeATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variantHyperinsulinism of infancy: towards an understanding of unregulated insulin release. European Network for Research into Hyperinsulinism in Infancy.Ions, genes and insulin release: from basic science to clinical disease. Based on the 1998 R. D. Lawrence Lecture.Is there a role for potassium channel openers in neuronal ion channel disorders?Congenital long QT syndromes and Brugada syndrome: the arrhythmogenic ion channel disorders.Peripheral channelopathies as targets for potassium channel openers.The molecular basis of the specificity of action of K(ATP) channel openers.Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K ATP channel.Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883AMuscle KATP channels: recent insights to energy sensing and myoprotectionHyperinsulinism in infancy: from basic science to clinical disease.K(ATP) channel therapeutics at the bedside.KATP Channels in the Cardiovascular System.Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex.Altered KATP Channel Subunits Expression and Vascular Reactivity in Spontaneously Hypertensive Rats With AgeAdvances in beta-cell imagingAdvances in molecular imaging of pancreatic beta cellsLessons in human biology from a monogenic pancreatic β cell disease.The therapeutic agents that target ATP-sensitive potassium channels.The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.Non-Markovian noise mediated through anomalous diffusion within ion channels.KATP channel openers of the benzopyran type reach their binding site via the cytosol.Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor.The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking.Four novel splice variants of sulfonylurea receptor 1.Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2.Syntaxin-1A interacts with distinct domains within nucleotide-binding folds of sulfonylurea receptor 1 to inhibit beta-cell ATP-sensitive potassium channels.Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.Differences in the mechanism of metabolic regulation of ATP-sensitive K+ channels containing Kir6.1 and Kir6.2 subunits.Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels.
P2860
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P2860
Identification of the potassium channel opener site on sulfonylurea receptors.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Identification of the potassium channel opener site on sulfonylurea receptors.
@ast
Identification of the potassium channel opener site on sulfonylurea receptors.
@en
type
label
Identification of the potassium channel opener site on sulfonylurea receptors.
@ast
Identification of the potassium channel opener site on sulfonylurea receptors.
@en
prefLabel
Identification of the potassium channel opener site on sulfonylurea receptors.
@ast
Identification of the potassium channel opener site on sulfonylurea receptors.
@en
P2093
P356
P1476
Identification of the potassium channel opener site on sulfonylurea receptors.
@en
P2093
Schwanstecher C
Schwanstecher M
P304
28079-28082
P356
10.1074/JBC.274.40.28079
P407
P577
1999-10-01T00:00:00Z