The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
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The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)Identification of novel VHL target genes and relationship to hypoxic response pathwaysCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinDual roles for the Dab2 adaptor protein in embryonic development and kidney transportThe adaptor protein Disabled-2: new insights into platelet biology and integrin signalingCell cycle-dependent phosphorylation of Disabled-2 by cdc2Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2PKB/Akt partners with Dab2 in albumin endocytosisThe inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancerType II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cellsLoss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines.Both the phosphoinositide and receptor binding activities of Dab1 are required for Reelin-stimulated Dab1 tyrosine phosphorylation.Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.Microcystin-LR induces apoptosis via NF-κB/iNOS pathway in INS-1 cellsInvasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight.Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis.Disabled-2: A modular scaffold protein with multifaceted functions in signaling.Disabled-2 small interfering RNA modulates cellular adhesive function and MAPK activity during megakaryocytic differentiation of K562 cells.Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells.Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.Adapter molecule DOC-2 is differentially expressed in pressure and volume overload hypertrophy and inhibits collagen synthesis in cardiac fibroblasts.Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets.
P2860
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P2860
The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
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1999年學術文章
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name
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@ast
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@en
type
label
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@ast
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@en
prefLabel
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@ast
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@en
P2093
P2860
P356
P1476
The role of DOC-2/DAB2 protein ...... e function in prostate cancer.
@en
P2093
P2860
P304
31981-31986
P356
10.1074/JBC.274.45.31981
P407
P577
1999-11-01T00:00:00Z