Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
about
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activityRothmund-Thomson syndromeCellular roles of dna topoisomerases: a molecular perspectiveHuman RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.Diverged nuclear localization of Werner helicase in human and mouse cellsStructural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein AIntron-size constraint as a mutational mechanism in Rothmund-Thomson syndromeNucleases in homologous recombination as targets for cancer therapyThe role of RecQ helicases in non-homologous end-joiningRECQL4 in genomic instability and agingThe DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formationStructure of the human RECQ1 helicase reveals a putative strand-separation pinThe N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motifRMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complexThe Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repairA human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308Mobility in the structure of E.coli recQ helicase upon substrate binding as seen from molecular dynamics simulations.Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA)dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationDifferential regulation of human RecQ family helicases in cell transformation and cell cycle.Biomarkers in Osteosarcoma.The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.The Sgs1 helicase of Saccharomyces cerevisiae inhibits retrotransposition of Ty1 multimeric arrays.WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.RecQ helicases: at the heart of genetic stability.Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A.Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype.The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patientsThe versatile RECQL4.Assessment of clinical analytical sensitivity and specificity of next-generation sequencing for detection of simple and complex mutationsRecQL4 helicase amplification is involved in human breast tumorigenesis.The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.RecQ helicases: suppressors of tumorigenesis and premature aging.The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.Development of autoimmunity in mice lacking DNA topoisomerase 3beta
P2860
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P2860
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@ast
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@en
type
label
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@ast
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@en
prefLabel
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@ast
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@en
P2093
P356
P1433
P1476
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
@en
P2093
P304
P356
10.1006/GENO.1999.5959
P577
1999-11-01T00:00:00Z