Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling
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BRCA Mutations, DNA Repair Deficiency, and Ovarian AgingFancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in miceFANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells.Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.Correction of a pathogenic gene mutation in human embryos.A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.
P2860
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P2860
Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2014年の論文
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2014年论文
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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P2093
P2860
P1433
P1476
Hypersensitivity of primordial ...... involves ATM-p53-p21 signaling
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P2093
John C Schimenti
Naoko Shima
Ruizhu Zeng
Teresa L Southard
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004471
P577
2014-07-10T00:00:00Z