Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
about
Visualizing functional motions of membrane transporters with molecular dynamics simulationsMechanisms of glutamate transportExcitatory amino acid transporters: roles in glutamatergic neurotransmissionMolecular dynamics simulations of the mammalian glutamate transporter EAAT3Binding thermodynamics of a glutamate transporter homologCoupled ion binding and structural transitions along the transport cycle of glutamate transportersNa+ interactions with the neutral amino acid transporter ASCT1.Molecular dynamics simulations elucidate the mechanism of proton transport in the glutamate transporter EAAT3The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter.Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1.New views of glutamate transporter structure and function: advances and challenges.Free energy simulations of ligand binding to the aspartate transporter Glt(Ph).Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding SiteA conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transportersStructural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh.Conserved asparagine residue located in binding pocket controls cation selectivity and substrate interactions in neuronal glutamate transporter.A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State.The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2.Computational Studies of Glutamate TransportersProtonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positionsVoltage-dependent processes in the electroneutral amino acid exchanger ASCT2SLC Transporters: Structure, Function, and Drug Discovery.Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.SLC1 glutamate transportersNeurotransmitter transporters: structure meets function.Molecular physiology of EAAT anion channels.Gating Charge Calculations by Computational Electrophysiology Simulations.Mother-to-child transmission of HIV in Kenya: A cross-sectional analysis of the national database over nine years.Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh.Structure and allosteric inhibition of excitatory amino acid transporter 1.Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk.Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members.Analysis of the quality of crystallographic data and the limitations of structural models.Consensus designs and thermal stability determinants of a human glutamate transporter
P2860
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P2860
Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@ast
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@en
type
label
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@ast
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@en
prefLabel
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@ast
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@en
P2093
P2860
P356
P1476
Mechanism of cation binding to ...... ved amino acid residue Thr101.
@en
P2093
Armanda Gameiro
Baruch I Kanner
Christof Grewer
Juddy Mwaura
Noa Rosental
P2860
P304
17725-17733
P356
10.1074/JBC.M110.121798
P407
P577
2010-04-08T00:00:00Z