Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. - Wikidata - awgldk - TriplyDB

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.

http://www.wikidata.org/entity/Q33885974

about

Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin The hitchhiker's guide to the voltage-gated sodium channel galaxy Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity Mammalian Neuronal Sodium Channel Blocker μ-Conotoxin BuIIIB Has a Structured N-Terminus That Influences Potency Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.μ-conotoxin KIIIA derivatives with divergent affinities versus efficacies in blocking voltage-gated sodium channels.Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion.Neurotoxins and their binding areas on voltage-gated sodium channels.μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker μ-KIIIA and its selenopeptide analogues Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.A candidate mechanism underlying the variance of interictal spike propagation.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins.Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.Pharmacological fractionation of tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons by μ-conotoxins A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ.The tetrodotoxin receptor of voltage-gated sodium channels--perspectives from interactions with micro-conotoxins.Animal toxins influence voltage-gated sodium channel function.Possible roles of exceptionally conserved residues around the selectivity filters of sodium and calcium channels Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity.Structural Models of Ligand-Bound Sodium Channels.NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

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Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.

http://www.wikidata.org/entity/Q33885974

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

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name

Synergistic and antagonistic i ...... voltage-gated sodium channels.

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Synergistic and antagonistic i ...... voltage-gated sodium channels.

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type

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Synergistic and antagonistic i ...... voltage-gated sodium channels.

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Synergistic and antagonistic i ...... voltage-gated sodium channels.

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Synergistic and antagonistic i ...... voltage-gated sodium channels.

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Synergistic and antagonistic i ...... voltage-gated sodium channels.

@en

P2093

Baldomero M Olivera

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Doju Yoshikami

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Grzegorz Bulaj

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Jeff R McArthur

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Layla Azam

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Min-Min Zhang

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Robert J French

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P2860

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.

Voltage-gated sodium channels and pain pathways.

Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.

Sodium channel toxins--receptor targeting and therapeutic potential.

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates.

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32-38

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scholarly article

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10.4161/CHAN.3.1.7500

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1

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3

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2009-01-25T00:00:00Z

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19221510

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2878737

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