Active unfolding of precursor proteins during mitochondrial protein import.
about
Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.Heat stress contributes to the enhancement of cardiac mitochondrial complex activityEffect of protein structure on mitochondrial import.Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytesRoles of Tom70 in import of presequence-containing mitochondrial proteins.A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression.Structural determinants of PINK1 topology and dual subcellular distributionProtein unfolding by mitochondria. The Hsp70 import motorPlasmodium vivax tryptophan-rich antigen PvTRAg33.5 contains alpha helical structure and multidomain architecture.Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.The protein import machinery of the mitochondrial membranes.Strong precursor-pore interactions constrain models for mitochondrial protein importComparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements.Ligand binding modulates the mechanical stability of dihydrofolate reductase.beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein.Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling.On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.Evidence of evolutionary constraints that influences the sequence composition and diversity of mitochondrial matrix targeting signalsCardiac mitochondrial complex activity is enhanced by heat shock proteins.Charge requirements for proton gradient-driven translocation of anthrax toxinThe molten globule state is unusually deformable under mechanical force.A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathwaysThe dimensions of the protein import channels in the outer and inner mitochondrial membranesCharacterization of PINK1 processing, stability, and subcellular localization.Pushing, pulling and trapping--modes of motor protein supported protein translocation.Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore.Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism.Protein sensing with engineered protein nanoporesATP-dependent proteases differ substantially in their ability to unfold globular proteinsEffect of the protein import machinery at the mitochondrial surface on precursor stabilityLethal factor unfolding is the most force-dependent step of anthrax toxin translocation.Tight knots in proteins: can they block the mitochondrial pores?Protein homeostasis defects of alanine-glyoxylate aminotransferase: new therapeutic strategies in primary hyperoxaluria type I.Role of membrane contact sites in protein import into mitochondria.Recognition of preproteins by the isolated TOM complex of mitochondria.Overexpression of yeast karyopherin Pse1p/Kap121p stimulates the mitochondrial import of hydrophobic proteins in vivo.Unfolding of preproteins upon import into mitochondria.Membrane potential-driven protein import into mitochondria. The sorting sequence of cytochrome b(2) modulates the deltapsi-dependence of translocation of the matrix-targeting sequence.Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.
P2860
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P2860
Active unfolding of precursor proteins during mitochondrial protein import.
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Active unfolding of precursor proteins during mitochondrial protein import.
@ast
Active unfolding of precursor proteins during mitochondrial protein import.
@en
type
label
Active unfolding of precursor proteins during mitochondrial protein import.
@ast
Active unfolding of precursor proteins during mitochondrial protein import.
@en
prefLabel
Active unfolding of precursor proteins during mitochondrial protein import.
@ast
Active unfolding of precursor proteins during mitochondrial protein import.
@en
P2093
P2860
P356
P1433
P1476
Active unfolding of precursor proteins during mitochondrial protein import.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/16.22.6727
P407
P577
1997-11-01T00:00:00Z