Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).
about
The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilinSulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulumThe protective role of prosaposin and its receptors in the nervous systemHuman acid ceramidase: processing, glycosylation, and lysosomal targetingNeurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid raftsLRP: a multifunctional scavenger and signaling receptorPurified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation.LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxinsImpaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutationsRole of prosaposin in the male reproductive system: effect of prosaposin inactivation on the testis, epididymis, prostate, and seminal vesicles.Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in miceBiosynthesis and degradation of mammalian glycosphingolipids.Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice.Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense.Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartmentsGlycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases.The immunological functions of saposins.My journey into the world of sphingolipids and sphingolipidoses.Progranulin, lysosomal regulation and neurodegenerative disease.News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.Prosaposin is a regulator of progranulin levels and oligomerization.Quantitative Proteome Analysis of Mouse Liver Lysosomes Provides Evidence for Mannose 6-phosphate-independent Targeting Mechanisms of Acid Hydrolases in Mucolipidosis II.A stretch of 17 amino acids in the prosaposin C terminus is critical for its binding to sortilin and targeting to lysosomes.Proteolytic processing of the gamma-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages.Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting.The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux.Prosaposin-derived peptide alleviates ischaemia-induced hearing loss.Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.
P2860
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P2860
Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@ast
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@en
type
label
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@ast
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@en
prefLabel
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@ast
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@en
P2093
P2860
P356
P1433
P1476
Cellular uptake of saposin (SA ...... eceptor-related protein (LRP).
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/17.16.4617
P407
P577
1998-08-01T00:00:00Z