Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.
about
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosisEctopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemiaA novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemiaPKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder.Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factorsIdentification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cellsZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5Signal transduction and cellular functions of the TEL/ARG oncoprotein.Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.STAT signaling in the pathogenesis and treatment of cancerPathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Lnk constrains myeloproliferative diseases in mice.Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581JAK-STAT signaling activated by Abl oncogenes.The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cellsPML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse modelA murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells.Proteins of the ETS family with transcriptional repressor activity.Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase.Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.BCR-JAK2 drives a myeloproliferative neoplasm in transplanted mice.Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.Cellular signalling pathways: new targets in leukaemia therapy.t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.Jak/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies.Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models.The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).Studying the pathogenesis of BCR-ABL+ leukemia in mice.p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.Regulation of cytokine receptor signaling by SOCS1.Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRAExpression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivoJAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.Signal transducers and activators of transcription: insights into the molecular basis of oral cancer.
P2860
Q24609999-03549E15-78C2-4389-AA25-17AEB0A96BE5Q24627258-B2BE065C-4E20-4633-B921-BB8955EE5DB5Q24685013-359E48C7-0268-45B7-BBEC-6434241AC5C8Q27824821-2F04AED4-162C-41BE-B395-03FD65377A5DQ28118868-03381D05-9DC1-47E9-B843-282EB7CD3123Q28594532-E787F292-2C24-433E-BBE3-FF876E9AF46DQ28609080-B1A2BD1B-D774-41A8-906A-06B9FC9B37A1Q30160307-7F78BA64-FC2A-40BD-9F4A-EDE75BEC634AQ33559005-CF696D22-35BA-4E66-B6B5-3FD93D2B4C62Q33712802-575EE0F6-0A8C-4C71-8132-D96FC4C9778BQ33753094-19A8E17A-73CA-42B0-9B4A-5CB0A80AC8F4Q33882944-81D99D70-A002-4C73-8582-D239156AEBD0Q33939204-A919EC3B-CC93-4D54-BE28-FEAFC0FBFA74Q33941370-8A158D2C-D603-4995-BA59-4CA6F87D0111Q33959545-FDD9080A-F6E6-491D-9417-335D206A6552Q34032333-51574FB6-B2D6-478F-BB84-FD84BE5A5C41Q34064832-9DD3C43F-6D4E-4123-A8D6-EDAFD590A422Q34065882-5571203F-B77B-47E3-AE05-058FB75E424AQ34087180-1C94D5D7-5AAC-4673-805A-CC2DD7D6B54CQ34139422-76045A2D-CD13-43C3-A8C3-0E694469CA38Q34182738-57A3B63B-F416-4D58-B3D3-1F86BE65AA59Q34245259-61ED4D6B-27B1-4DEC-8E25-DC8C4CB6D284Q34461890-80F622FC-13DE-4849-AA84-1B7790104B30Q34486039-D45665FF-F37E-40E7-9460-79B31576CC90Q34527660-F53571D5-6ADF-46DA-B0CC-39464A505C52Q34570939-ADE4079E-12C2-45F3-B7D8-8D4D8469D79BQ34718163-86DE84BC-BA79-4BDE-84DC-C50E84566D42Q34980358-B9C9B4EC-B848-403A-941C-3AB75817F6E1Q35018563-1089AA26-F6B0-48CA-9CF0-2C4EA4E2010BQ35022543-C406BD22-043D-4C73-88F6-D626CCEC44FAQ35083267-F0F44FCC-C72A-4938-B1C9-3CF3A85D84C9Q35096707-022ABA33-8FC7-4EBE-96EA-15EE2701307AQ35114558-9ADA7D28-FD93-4DA6-ACBE-CA3F76512BECQ35120026-A339255E-FD01-459A-875A-9B00C3474E7FQ35635353-16113695-2D8B-4CE7-A329-721AC8CFBE75Q35847967-4ABC59D2-84AF-47C5-8833-D65B8AC7A77DQ35849213-61E61EC5-C3CD-411A-A39D-B82795047FE3Q35849674-341D0A51-6978-4427-B704-58164D1BF9DDQ35850692-041A0550-07B8-4DA4-9B23-9756F44621B4Q35911353-25409363-2249-41D1-BA22-775B66E09447
P2860
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@ast
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@en
type
label
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@ast
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@en
prefLabel
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@ast
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@en
P2093
P2860
P356
P1433
P1476
Transformation of hematopoieti ...... nsduced TEL/JAK2 fusion genes.
@en
P2093
D G Gilliland
I R Williams
J Frantsve
J Schwaller
L Van Rompaey
M H Tomasson
R A Van Etten
P2860
P304
P356
10.1093/EMBOJ/17.18.5321
P407
P577
1998-09-01T00:00:00Z