APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
about
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and NotchAlzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formationTransmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexSyntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationPresenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryWhen loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseThe presenilinsDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal ModelsToward the structure of presenilin/γ-secretase and presenilin homologsAPP processing in Alzheimer's diseaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsAn atomic structure of human γ-secretaseA conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complexBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseTime-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissuesA nine-transmembrane domain topology for presenilin 1Assembly, trafficking and function of gamma-secretasePen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathwayPresenilin 1 is required for maturation and cell surface accumulation of nicastrinSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.Structural basis of human γ-secretase assembly.Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".CSF biomarkers for mild cognitive impairment.Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.A miniaturized 1536-well format gamma-secretase assayAllosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoTransgenic models of Alzheimer's disease: learning from animalsThe initial substrate-binding site of gamma-secretase is located on presenilin near the active siteCrystal structure of the γ-secretase component nicastrin.
P2860
Q24307727-189199EB-1DBF-454E-8E0F-C68414156E39Q24314297-288BA9D7-79A5-410B-889C-12318816B57AQ24318823-5DC12ACA-AB05-4218-BBA2-6205C9F7A3D3Q24528112-D777C0E5-9388-478B-B957-9B0F8F2DFB5DQ24530721-17523416-3BF8-4B8B-A78C-1CF9BAF97E39Q24541447-3493C573-6F8A-451D-8B60-6546898CCAC3Q24630927-104BD514-09CB-48CC-A078-3B81D25DD436Q24676480-12C9BB06-E961-4D17-8616-72099162C64EQ24806449-9E8D9080-B442-48E0-93D5-AB448FC8E1B7Q26750648-7DDA1888-12EE-4328-91CC-1163E68400D9Q27002018-7BD771F3-8C8A-4234-8488-97E2C16629E5Q27694738-590EC5B3-2D00-4BFC-AD02-ADE2CB0AC2E5Q28080576-72C5917C-B759-49C2-A324-5A9AB915C99BQ28116260-1D64C989-604E-4242-B935-573FCED1EA73Q28185671-9AED2DAD-3FE9-4056-8BFF-02B5714753EAQ28257726-E4BD9403-FB0F-4393-A9F2-9A6E4773A01BQ28262008-6FD94094-1110-4F95-BE85-92A08D86C49AQ28263814-C04483E1-486B-46D4-9575-3129074F68A7Q28268951-479E1C8F-04D8-4DB9-8B1E-AC2A50F6E257Q28277779-9D66E6C8-0D5E-4F94-9B93-F7DBABDEE369Q28285387-EA8FBB24-024A-407E-B825-2CB51F078903Q28510523-5B058CAC-F7A5-4563-88C6-9D98D9A93A86Q28591973-53358FCB-6DA3-4876-8C18-C97853EDE615Q30336360-30175393-29E2-4BFD-BD5A-61053A8E0B83Q30363483-684CD67E-361C-40D4-B52E-8A96A7269162Q30650829-CCA8EB6C-0100-4B0B-9FAC-10219352F8B9Q30780773-EA07CFBC-713A-45C8-AAD7-2A23F782A939Q30876784-A126AD91-EF51-45C7-893A-EB9D594C1753Q30953185-96FB63D2-3F25-41CF-820A-E99DB8F9FA15Q31157217-20618FA7-721F-4425-B94E-80BA7F76B12EQ33206144-E67E9600-27A4-4B22-91CD-91303280884FQ33276402-21EE8607-0F7B-49C8-AD21-2E255C5312A2Q33327152-9B566172-309A-4551-82F8-7046CCA38F2AQ33498093-34968C7A-4C00-47F2-AE28-D387BAAD5A15Q33516237-A6EFA1C4-F366-4233-B3DE-533E381AC7A8Q33726342-F1DEEA4C-CC80-4BB0-B3DB-DED53CE87008Q33810588-DF98CCE6-83D5-4C5B-A336-CE3E609AD386Q33844718-19077A94-E852-49A3-B9A4-475105CF7540Q33927461-036FEB25-8768-40B3-85E6-0E778501FFCCQ34218060-9341C536-D2CE-4BCA-8766-FA5069C88CB3
P2860
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@ast
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@en
type
label
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@ast
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@en
prefLabel
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@ast
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@en
P2093
P2860
P356
P1476
APH-1 is a multipass membrane ...... Caenorhabditis elegans embryos
@en
P2093
Caroline Goutte
James R Priess
Makoto Tsunozaki
Valerie A Hale
P2860
P304
P356
10.1073/PNAS.022523499
P407
P577
2002-01-15T00:00:00Z