In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus
about
Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis.Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeysGeneration and characterization of human anti-human IL-21 neutralizing monoclonal antibodiesPharmacokinetics and toxicology of therapeutic proteins: Advances and challenges.Absorption, distribution, metabolism, and excretion (ADME) studies of biotherapeutics for autoimmune and inflammatory conditions.T cells, murine chronic graft-versus-host disease and autoimmunity.pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood.The rapid generation of recombinant functional monoclonal antibodies from individual, antigen-specific bone marrow-derived plasma cells isolated using a novel fluorescence-based method.Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?T cells that promote B-Cell maturation in systemic autoimmunityPharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.A strategy for risk mitigation of antibodies with fast clearance.IL-21 Receptor Antagonist Inhibits Differentiation of B Cells toward Plasmablasts upon Alloantigen Stimulation.T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses?Anti-neuropilin-1 (MNRP1685A): unexpected pharmacokinetic differences across species, from preclinical models to humans.Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study.Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
P2860
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P2860
In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@ast
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@en
type
label
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@ast
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@en
prefLabel
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@ast
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@en
P2093
P2860
P356
P1476
In vitro potency, pharmacokine ...... dies in a mouse model of lupus
@en
P2093
Angela Widom
David Lowe
Davinder Gill
Deborah Young
Frann Bennett
George Thom
Heath Guay
Laird Bloom
Leslie Lowe
P2860
P304
P356
10.4161/MABS.2.3.11850
P577
2010-05-23T00:00:00Z