GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.
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Yersinia controls type III effector delivery into host cells by modulating Rho activityThe RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence functionThe Yersinia YopE and YopH type III effector proteins enhance bacterial proliferation following contact with eukaryotic cellsYersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1.Yeast as a Heterologous Model System to Uncover Type III Effector FunctionStructure of the ExoS GTPase activating domainCrystal structure of the Yersinia pestis GTPase activator YopEStructural mimicry in bacterial virulenceHow do microbes evade neutrophil killing?A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranesProtein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant- and animal-pathogenic bacteria.The C terminus of YopT is crucial for activity and the N terminus is crucial for substrate binding.Identification of residues in the N-terminal domain of the Yersinia tyrosine phosphatase that are critical for substrate recognition.Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systemsYeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulationA functional genomic yeast screen to identify pathogenic bacterial proteinsYersinia outer protein YopE affects the actin cytoskeleton in Dictyostelium discoideum through targeting of multiple Rho family GTPasesMycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages.Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB proteinCompetition between the Yops of Yersinia enterocolitica for delivery into eukaryotic cells: role of the SycE chaperone binding domain of YopE.The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulenceEffector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infectionROS-inhibitory activity of YopE is required for full virulence of Yersinia in miceThe arginine finger domain of ExoT contributes to actin cytoskeleton disruption and inhibition of internalization of Pseudomonas aeruginosa by epithelial cells and macrophages.The type III secretion system tip complex and translocon.Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection.In vivo rho GTPase-activating protein activity of Pseudomonas aeruginosa cytotoxin ExoSDNA adenine methylase overproduction in Yersinia pseudotuberculosis alters YopE expression and secretion and host immune responses to infection.Yersinia pseudotuberculosis produces a cytotoxic necrotizing factorRole of Yops and adhesins in resistance of Yersinia enterocolitica to phagocytosis.Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host.Expression of the Salmonella spp. virulence factor SifA in yeast alters Rho1 activity on peroxisomes.Alternative endogenous protein processing via an autophagy-dependent pathway compensates for Yersinia-mediated inhibition of endosomal major histocompatibility complex class II antigen presentation.MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion systemPathogenic trickery: deception of host cell processes.Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.Yersinia enterocolitica YopT and Clostridium difficile toxin B induce expression of GILZ in epithelial cellsDisturbance of endothelial barrier function by bacterial toxins and atherogenic mediators: a role for Rho/Rho kinase.Comparison of YopE and YopT activities in counteracting host signalling responses to Yersinia pseudotuberculosis infection.
P2860
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P2860
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
GAP activity of the Yersinia Y ...... actin microfilament structure.
@ast
GAP activity of the Yersinia Y ...... actin microfilament structure.
@en
type
label
GAP activity of the Yersinia Y ...... actin microfilament structure.
@ast
GAP activity of the Yersinia Y ...... actin microfilament structure.
@en
prefLabel
GAP activity of the Yersinia Y ...... actin microfilament structure.
@ast
GAP activity of the Yersinia Y ...... actin microfilament structure.
@en
P2093
P2860
P1476
GAP activity of the Yersinia Y ...... actin microfilament structure.
@en
P2093
Aktories K
Rosqvist R
Telepnev MV
Von Pawel-Rammingen U
Wolf-Watz H
P2860
P304
P356
10.1046/J.1365-2958.2000.01898.X
P407
P577
2000-05-01T00:00:00Z