Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.
about
CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndromeSynthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists.Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugsMarked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs.Therapeutic potential of CRF receptor antagonists: a gut-brain perspective.On the role of corticotropin-releasing hormone receptors in anxiety and depressionFrom Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases.Peptide interactions with G-protein coupled receptors.The therapeutic potential of CRF1 antagonists for anxiety.Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.The corticotropin-releasing factor receptor: a novel target for the treatment of depression and anxiety-related disorders.Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear.Prospects for the treatment of depression.Emerging treatments for major depression.Allosteric modulators of class B G-protein-coupled receptorsCorticotropin-releasing factor receptor antagonists.Drug-target residence time--a case for G protein-coupled receptors.Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats.Synthesis of new thiazolo[4,5-d]pyrimidines as Corticotropin releasing factor modulators.Synthesis and Biological Evaluation of New CRH AnaloguesCRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents.Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2.Peripheral CRF activates myenteric neurons in the proximal colon through CRF(1) receptor in conscious rats.Structure-activity studies on the corticotropin releasing factor antagonist astressin, leading to a minimal sequence necessary for antagonistic activity.Anti-stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic-Pituitary-Adrenal Axis.Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors
P2860
Q24671910-D7DD6F42-403D-4430-91E8-C339BD0A64FCQ30745494-CA047BC2-1A66-4FDC-BC0B-085CA0D0790EQ33289718-A254A8CE-CF73-4EAE-8804-B6D142159FBCQ34135209-2440A9D2-6436-4644-B918-FF49B0338358Q34204338-E60E5680-8F30-4D1D-A4F0-666C3BE3344BQ34228120-DC4847CB-CA8C-4B6B-885F-9BA352E2A456Q34357345-504B3B9F-D371-4F26-B8B8-BC897B25ADB3Q34483031-62CCC091-77D2-4B7D-AEAA-719404FB0515Q35814456-3D3A0F76-6BB6-42E7-A302-3229B56051C9Q35894035-10AA4A02-11CD-47F9-8DA7-3716375F0AF3Q36219686-D500D14C-53D9-43FD-B02A-21558F25541EQ36327724-78E9FEA5-9452-4DDD-BA2B-D16D96BF0C5FQ36472992-093DC5C5-7022-4421-9A0D-7B38E162E020Q36730674-3E179E40-D571-4B51-A907-85D4DBB9932BQ37131132-C26B0184-B805-42E0-9D31-5D4EBBF9FFEAQ37689780-8479F720-BDA0-409D-B5C0-10A49F119F0DQ38189272-1FF3A261-258B-457E-8A30-E0CCBD33E810Q41010507-0B7577CE-A2C1-49DB-92AF-CC3BFF18E4F6Q42533202-12258962-9CDC-459D-9425-E3306B3595F3Q42727611-63D03AAA-E531-46E9-BD34-A64AB0F1BB45Q43535348-9BFC8DCC-F4D0-40CA-A466-41CAF8910EAEQ43771149-0E28F289-E4E8-476C-808B-F0735E1EF890Q43964302-5DE62E41-FF6C-49CF-9082-6220F997F7D7Q44784411-3A6F8770-8A3E-47D5-9C30-BA88FE45735CQ48890067-68CF4EF3-952D-4194-A51E-96745984855FQ56991997-447F96DE-48DB-4D99-B69C-48C3A84DD819
P2860
Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
name
Corticotropin releasing factor ...... es for new therapeutic agents.
@ast
Corticotropin releasing factor ...... es for new therapeutic agents.
@en
type
label
Corticotropin releasing factor ...... es for new therapeutic agents.
@ast
Corticotropin releasing factor ...... es for new therapeutic agents.
@en
prefLabel
Corticotropin releasing factor ...... es for new therapeutic agents.
@ast
Corticotropin releasing factor ...... es for new therapeutic agents.
@en
P2093
P356
P1476
Corticotropin releasing factor ...... es for new therapeutic agents.
@en
P2093
Gilligan PJ
Robertson DW
P304
P356
10.1021/JM990590F
P407
P577
2000-05-01T00:00:00Z