Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis - Wikidata - awgldk - TriplyDB

Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis

Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis

http://www.wikidata.org/entity/Q33906596

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Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders Elusive roles for reactive astrocytes in neurodegenerative diseases Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits TFEB at a glance Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment.Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective The lysosome as a command-and-control center for cellular metabolism.New advances on glial activation in health and disease.Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead.Iron and Neurodegeneration: Is Ferritinophagy the Link?Astrocytes: a central element in neurological diseases.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Mechanisms of cellular plasticity in cerebral perivascular region.Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases.Astrocyte dysfunction in Alzheimer disease.Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy.The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases.Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer's and Amyotrophic Lateral Sclerosis Brains.Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease.Impaired Protein Quality Control During Left Ventricular Remodeling in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor.Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.Diversity of astroglial responses across human neurodegenerative disorders and brain aging.

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Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis

http://www.wikidata.org/entity/Q33906596

description

2014 nî lūn-bûn

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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2014 թվականի հուլիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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type

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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JNEUROSCI.3788-13.2014

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Journal of Neuroscience

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Enhancing astrocytic lysosome ...... es amyloid plaque pathogenesis

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Abhinav Diwan

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Alec Zhu

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Dorothy R Schuler

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Ernesto Gonzales

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Haiyan Liu

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Jack M Burchett

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John R Cirrito

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Ping Yan

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Qingli Xiao

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Ronaldo Perez

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P2860

A gene network regulating lysosomal biogenesis and function

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

A heparan sulfate-facilitated and raft-dependent macropinocytosis of eosinophil cationic protein

mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease

The mystery and magic of glia: a perspective on their roles in health and disease

Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

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9607-9620

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10.1523/JNEUROSCI.3788-13.2014

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