Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin

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http://www.wikidata.org/entity/Q33908521

Q33908521

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Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).Cyclization of aromatic polyketides from bacteria and fungi Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain.Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster.Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4 Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII Bioactive compounds from marine actinomycetes.Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis.Generation of new compounds through unbalanced transcription of landomycin A cluster.Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis.Nocardiopsistins A-C: New angucyclines with anti-MRSA activity isolated from a marine sponge-derived sp. HB-J378

P2860

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P2860

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin

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http://www.wikidata.org/entity/Q33908521

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2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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