mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning - Wikidata - awgldk - TriplyDB

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

http://www.wikidata.org/entity/Q33908562

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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin Gene networks associated with conditional fear in mice identified using a systems genetics approach.Allosteric modulation of metabotropic glutamate receptors.Advancing drug discovery for schizophrenia.Targeting glutamate synapses in schizophrenia Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5 Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.Imaging glutamate in schizophrenia: review of findings and implications for drug discovery.mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.The NMDA receptor as a target for cognitive enhancement Development of allosteric modulators of GPCRs for treatment of CNS disorders Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task Glutamatergic targets for enhancing extinction learning in drug addiction CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.Cognitive enhancers for facilitating drug cue extinction: insights from animal models.The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease.Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex

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P2860

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

http://www.wikidata.org/entity/Q33908562

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2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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Neuropsychopharmacology

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mGluR5 positive allosteric mod ...... D and enhance spatial learning

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Alexandra N Telk

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Douglas J Sheffler

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Jennifer E Ayala

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Jessica L Banko

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M Foster Olive

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Noreen L Watson

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Paulianda J Jones

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Richard Williams

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Yelin Chen

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Yongqin Zhang

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P2860

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression

The mGluR theory of fragile X mental retardation

Pharmacology and functions of metabotropic glutamate receptors

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

MGluR5 mediates the interaction between late-LTP, network activity, and learning

Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus.

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2057-2071

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scholarly article

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10.1038/NPP.2009.30

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9

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34

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Craig W. Lindsley

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2009-03-18T00:00:00Z

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24209520

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1025854513

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19295507

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2884290

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