Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains
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Targeting p97 to Disrupt Protein Homeostasis in CancerMutations in the Human AAA+ Chaperone p97 and Related DiseasesRare Manifestation of a c.290 C>T, p.Gly97Glu VCP MutationAltered cofactor regulation with disease-associated p97/VCP mutationsControl of p97 function by cofactor bindingDendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and ProgressionA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex.A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly.Functional chromatographic technique for natural product isolationInhibitors of the AAA+ chaperone p97Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.Structure and function of the AAA+ ATPase p97/Cdc48p.Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858).A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair.p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97.Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes.Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor.VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase.Structural basis for nucleotide-modulated p97 association with the ER membrane.Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding.A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases.Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors.Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.AtCDC48A is involved in the turnover of an NLR immune receptor.Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.
P2860
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P2860
Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains
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2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-hans
2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@ast
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@en
type
label
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@ast
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@en
prefLabel
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@ast
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@en
P2093
P2860
P1476
Specific inhibition of p97/VCP ...... tween D1 and D2 ATPase domains
@en
P2093
Conrad C Weihl
Frank J Schoenen
Henry J Lin
Michelle R Arkin
Raymond J Deshaies
Stacie L Bulfer
P2860
P304
P356
10.1016/J.JMB.2014.05.022
P407
P577
2014-05-27T00:00:00Z