Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. - Wikidata - awgldk - TriplyDB

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

http://www.wikidata.org/entity/Q33918375

about

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Interleukin-2 receptor signaling: at the interface between tolerance and immunity Shared and distinct genetic variants in type 1 diabetes and celiac disease A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes Newly identified genetic risk variants for celiac disease related to the immune response Inducing and Administering Tregs to Treat Human Disease The Non-Obese Diabetic Mouse Strain as a Model to Study CD8(+) T Cell Function in Relapsing and Progressive Multiple Sclerosis Low-dose interleukin-2 therapy: a driver of an imbalance between immune tolerance and autoimmunity From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines Recent advances in the genetics of autoimmune disease Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5 IL-21: roles in immunopathology and cancer therapy Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Regulatory T cells and vasectomy H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy Genetics of type 1 diabetes: what's next?IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravis Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity.Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.Idd9.1 locus controls the suppressive activity of FoxP3+CD4+CD25+ regulatory T-cells Once a Treg, always a Treg?Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects Fine-mapping resolves Eae23 into two QTLs and implicates ZEB1 as a candidate gene regulating experimental neuroinflammation in rat.Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

http://www.wikidata.org/entity/Q33918375

description

2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Nature Genetics

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.

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Andrea Gonzalez-Munoz

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Anne Marie Cumiskey

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Barry Healy

http://www.w3.org/2001/XMLSchema#string

Dan Rainbow

http://www.w3.org/2001/XMLSchema#string

David V Serreze

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Jan Clark

http://www.w3.org/2001/XMLSchema#string

Jane Rogers

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Jun Yamanouchi

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Kara Hunter

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Laurence B Peterson

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P2860

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

T1DBase, a community web-based resource for type 1 diabetes research

Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells

Multiple immuno-regulatory defects in type-1 diabetes

Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

SSAHA: a fast search method for large DNA databases

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node.

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329-337

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10.1038/NG1958

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3

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39

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6526557

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17277778

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2886969

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