Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
about
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entryDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virusTMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike proteinIdentification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assayViral and developmental cell fusion mechanisms: conservation and divergenceRespiratory viruses other than influenza virus: impact and therapeutic advancesMechanisms of coronavirus cell entry mediated by the viral spike proteinConformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusionFunctional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaquesEzrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stageDecoding protein networks during virus entry by quantitative proteomicsUnexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinasesTime- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered EntryProcessing of Capsid Protein by Cathepsin L Plays a Crucial Role in Replication of Japanese Encephalitis Virus in Neural and Macrophage CellsRole of Endocytosis and Low pH in Murine Hepatitis Virus Strain A59 Cell EntryViral membrane fusionStructures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common ThemeReceptor Binding and Low pH Coactivate Oncogenic Retrovirus Envelope-Mediated FusionEbolavirus glycoprotein structure and mechanism of entryFusion of Enveloped Viruses in Endosomes.Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infectionReceptor-induced thiolate couples Env activation to retrovirus fusion and infectionInfluenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tractsAbelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining stepReceptor-binding domain as a target for developing SARS vaccines.Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a TriggerDESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Pre-fusion structure of a human coronavirus spike protein.Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7.Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysisRole of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein.Chemical microarray: a new tool for drug screening and discovery.Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin LSevere fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell linesThe identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L.QSAR models for predicting cathepsin B inhibition by small molecules--continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules.Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability
P2860
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P2860
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@ast
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@en
type
label
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@ast
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@en
prefLabel
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@ast
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@en
P2093
P2860
P50
P356
P1476
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
@en
P2093
Dhaval N Gosalia
Jacqueline D Reeves
Scott L Diamond
P2860
P304
11876-11881
P356
10.1073/PNAS.0505577102
P407
P577
2005-08-04T00:00:00Z