Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors
about
The Sortase A Enzyme That Attaches Proteins to the Cell Wall of Bacillus anthracis Contains an Unusual Active Site ArchitectureMethicillin-resistant Staphylococcus aureus (MRSA) Pyruvate Kinase as a Target for Bis-indole Alkaloids with Antibacterial ActivitiesCovalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsStructure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESSNMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.In vitro selection of functional lantipeptides.Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation.Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).Targeting virulence not viability in the search for future antibacterials.An exhaustive yet simple virtual screening campaign against Sortase A from multiple drug resistant Staphylococcus aureus.Sortase-Mediated Transpeptidation for Site-Specific Modification of Peptides, Glycopeptides, and Proteins.Development of Potent and Selective S. aureus Sortase A Inhibitors Based on Peptide Macrocycles.Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.Exploration of multiple Sortase A protein conformations in virtual screeningDiscovery of Staphylococcus aureus sortase A inhibitors using virtual screening and the relaxed complex scheme.Viable screening targets related to the bacterial cell wall.The post-antibiotic era: promising developments in the therapy of infectious diseases.Antiadhesion agents against Gram-positive pathogens.Chinese herb medicine against Sortase A catalyzed transformations, a key role in gram-positive bacterial infection progress.Equilibrium of sortase A dimerization on Staphylococcus aureus cell surface mediates its cell wall sorting activity.4-[(tert-Butyl-diphenyl-sil-yloxy)meth-yl]pyridazin-3(2H)-one.Identification of 1-chloro-2-formyl indenes and tetralenes as novel antistaphylococcal agents exhibiting sortase A inhibition.Structural Analysis of Sortase A Inhibitors.5-[(tert-Butyl-diphenyl-sil-yloxy)meth-yl]pyridazin-3(2H)-one.Molecular Docking and Screening Studies of New Natural Sortase A Inhibitors.Combined pharmacophore and 3D-QSAR study on a series of Staphylococcus aureus Sortase A inhibitors.New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking.Recent developments with rhodanine as a scaffold for drug discovery.Late-stage diversification of biologically active pyridazinones via a direct C-H functionalization strategy.Erianin against Infection via Inhibiting Sortase A
P2860
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P2860
Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Discovery and structure-activi ...... us aureus sortase A inhibitors
@ast
Discovery and structure-activi ...... us aureus sortase A inhibitors
@en
type
label
Discovery and structure-activi ...... us aureus sortase A inhibitors
@ast
Discovery and structure-activi ...... us aureus sortase A inhibitors
@en
prefLabel
Discovery and structure-activi ...... us aureus sortase A inhibitors
@ast
Discovery and structure-activi ...... us aureus sortase A inhibitors
@en
P2093
P2860
P1476
Discovery and structure-activi ...... us aureus sortase A inhibitors
@en
P2093
Albert Chan
Melanie Marohn
Michael E Jung
Nuttee Suree
Robert Damoiseaux
Robert T Clubb
Sung Wook Yi
William Thieu
P2860
P304
P356
10.1016/J.BMC.2009.08.067
P407
P577
2009-09-06T00:00:00Z