Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.
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New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disordersGlobal biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans.Biological Activity and Antidiabetic Potential of C-Terminal Octapeptide Fragments of the Gut-Derived Hormone Xenin.Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes.Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.Neurotensin and its receptors in the control of glucose homeostasis.Xenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons.Inter-organ communication and regulation of beta cell functionUnraveling the mechanisms underlying olanzapine-induced insulin resistance.The combination of GIP plus xenin-25 indirectly increases pancreatic polypeptide release in humans with and without type 2 diabetes mellitus.c-Fos induction by gut hormones and extracellular ATP in osteoblastic-like cell lines.Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.Dietary steamed wheat bran increases postprandial fat oxidation in association with a reduced blood glucose-dependent insulinotropic polypeptide response in miceMetabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgeryGIP: no longer the neglected incretin twin?Xenin-25[Lys13PAL]: a novel long-acting acylated analogue of xenin-25 with promising antidiabetic potential.Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways.Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents.Xenin is a novel anorexigen in goldfish (Carassius auratus).Cholinergic signaling mediates the effects of xenin-25 on secretion of pancreatic polypeptide but not insulin or glucagon in humans with impaired glucose tolerance.
P2860
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P2860
Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@ast
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@en
type
label
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@ast
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@en
prefLabel
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@ast
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@en
P2093
P2860
P356
P1476
Xenin-25 potentiates glucose-d ...... l cholinergic relay mechanism.
@en
P2093
Burton M Wice
Dan L Crimmins
Eric L Ford
Jack H Ladenson
Kelly A Diggs-Andrews
Kenneth S Polonsky
Matthew C Althage
Matthew Ohlendorf
Qiuling Wang
P2860
P304
19842-19853
P356
10.1074/JBC.M110.129304
P407
P577
2010-04-26T00:00:00Z