17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention - Wikidata - awgldk - TriplyDB

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention

17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention

http://www.wikidata.org/entity/Q33927741

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Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease High-fat diet impairs spatial memory and hippocampal intrinsic excitability and sex-dependently alters circulating insulin and hippocampal insulin sensitivity Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.The effects of aging on the BTBR mouse model of autism spectrum disorder.Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice.Estrogen: a master regulator of bioenergetic systems in the brain and body Estrogen-Related Factors in the Frontal Lobe of Alzheimer's Disease Patients and Importance of Body Mass Index.Non-feminizing estrogens: a novel neuroprotective therapy.Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice.Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention Sex differences in cognitive impairment and Alzheimer's disease.Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways.BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats.Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease.Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity Neuroprotection by diarylpropionitrile in mice with spinal cord injury Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease Gender, sex steroid hormones, and Alzheimer's disease.Estrogen receptor β in Alzheimer's disease: From mechanisms to therapeutics.17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain The cerebellum as a target for estrogen action.Prognostic factors in paediatric anaplastic large cell lymphoma: role of ALK.Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition?Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis.Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition Sex and the development of Alzheimer's disease.Change in brain and lesion volumes after CEE therapies: the WHIMS-MRI studies Neuroendocrinology-based therapy for Alzheimer's disease.Targeting estrogen receptors for the treatment of Alzheimer's disease.Risks and benefits related to alimentary exposure to xenoestrogens.Sex Hormones Protect Against Amyloid-β Induced Oxidative Stress in the Choroid Plexus Cell Line Z310.BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.Sex Hormone Decline and Amyloid β Synthesis, Transport and Clearance in the Brain.Engineering poly(lactic-co-glycolic acid) (PLGA) micro- and nano-carriers for Controlled Delivery of 17β-Estradiol.Human ApoE ɛ2 Promotes Regulatory Mechanisms of Bioenergetic and Synaptic Function in Female Brain: A Focus on V-type H+-ATPase.Estrogen and insulin transport through the blood-brain barrier

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17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention

http://www.wikidata.org/entity/Q33927741

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2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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J.NEUROBIOLAGING.2009.12.010

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Neurobiology of Aging

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17β-Estradiol regulates insuli ...... ance to Alzheimer's prevention

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Jia Yao

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Liqin Zhao

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Roberta Diaz Brinton

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Shuhua Chen

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Zisu Mao

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P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

Insulin degradation: progress and potential

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action

Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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1949-1963

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11

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40869429

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20053478

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Alzheimer's disease

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2889185

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