Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation.
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Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chainsAnti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cellsDifferential regulation of survivin expression and apoptosis by vitamin D3 compounds in two isogenic MCF-7 breast cancer cell sublinesComputer-aided de novo ligand design and docking/molecular dynamics study of vitamin D receptor agonists.Restoration of the anti-proliferative and anti-migratory effects of 1,25-dihydroxyvitamin D by silibinin in vitamin D-resistant colon cancer cells.Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3.Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin DVitamin D and cancer: clinical aspects.A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinomaVitamin d: are we ready to supplement for breast cancer prevention and treatment?Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer.A role for interleukin-1 alpha in the 1,25 dihydroxyvitamin D3 response in mammary epithelial cells.The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung.G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer.Expression of vitamin D receptor as a potential prognostic factor and therapeutic target in pancreatic cancer.Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells.Vitamin D analog EB1089 induces apoptosis in a subpopulation of SGC-7901 gastric cancer cells through a mitochondrial-dependent apoptotic pathway.An advanced image analysis tool for the quantification and characterization of breast cancer in microscopy images.Autocrine TGFbeta signaling mediates vitamin D3 analog-induced growth inhibition in breast cells.Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination.Vitamin D analog EB1089 could repair the defective bone marrow-derived mesenchymal stromal cells in patients with systemic lupus erythematosus.Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells.Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D.
P2860
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P2860
Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation.
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2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@ast
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@en
type
label
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@ast
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@en
prefLabel
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@ast
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@en
P2093
P356
P1476
Seocalcitol (EB 1089): a vitam ...... nical and clinical evaluation.
@en
P2093
Binderup E
Binderup L
Hamberg KJ
P304
P356
10.2174/1381612003400371
P577
2000-05-01T00:00:00Z