Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.

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http://www.wikidata.org/entity/Q33930057
Bcl-2 antagonists: a proof of concept for CLL therapyTargeting the apoptosis pathway in hematologic malignanciesSmall molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapyThe Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studiesInhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.Programmed cell death pathways and current antitumor targets.An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals.PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma.Targeted treatment and new agents in diffuse large B cell lymphoma.Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies.Recent advances in gossypol derivatives and analogs: a chemistry and biology view.Physiological and Pharmacological Control of BAK, BAX, and Beyond.Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.Apogossypolone (ApoG2) induces ROS-dependent apoptosis and reduces invasiveness of PC12 cells in vitro and in vivo.Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells.
P2860

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.

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http://www.wikidata.org/entity/Q33930057
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2008 nî lūn-bûn
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2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
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Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
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type
label
Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
@ast
Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
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prefLabel
Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
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Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
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P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
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P1433
P1476
Apogossypolone, a nonpeptidic ...... ma cells in vitro and in vivo.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P5875
P698
P932