Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes - Wikidata - awgldk - TriplyDB

Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes

Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes

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Stability-mediated epistasis constrains the evolution of an influenza protein Genomic signatures of human versus avian influenza A viruses The genomic and epidemiological dynamics of human influenza A virus Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head Universal immunity to influenza must outwit immune evasion Advancements in the development of subunit influenza vaccines Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo Cell-mediated protection in influenza infection.Human cytotoxic T lymphocytes directed to seasonal influenza A viruses cross-react with the newly emerging H7N9 virus Immunogenicity of novel consensus-based DNA vaccines against avian influenza.Prior population immunity reduces the expected impact of CTL-inducing vaccines for pandemic influenza control.Switch region for pathogenic structural change in conformational disease and its prediction A heat-inactivated H7N3 vaccine induces cross-reactive cellular immunity in HLA-A2.1 transgenic mice.Influenza A Virus Infection in Pigs Attracts Multifunctional and Cross-Reactive T Cells to the Lung.Immunity to seasonal and pandemic influenza A viruses Targets for the induction of protective immunity against influenza a viruses.Induction of virus-specific cytotoxic T lymphocytes as a basis for the development of broadly protective influenza vaccines Detection of site-specific positive Darwinian selection on pandemic influenza A/H1N1 virus genome: integrative approaches.The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin.The genomic rate of molecular adaptation of the human influenza A virus Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity The polyclonal CD8 T cell response to influenza M158-66 generates a fully connected network of cross-reactive clonotypes to structurally related peptides: a paradigm for memory repertoire coverage of novel epitopes or escape mutants Positive Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages.Differential Recognition of Influenza A Viruses by M158-66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.HLA class I molecules consistently present internal influenza epitopes T-cell tolerance for variability in an HLA class I-presented influenza A virus epitope.Correlates of vaccine protection from influenza and its complications.Evasion of influenza A viruses from innate and adaptive immune responses.Influenza infection in human host: challenges in making a better influenza vaccine.High conservation level of CD8(+) T cell immunogenic regions within an unusual H1N2 human influenza variant.Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1 The hypervariable immunodominant NP418-426 epitope from the influenza A virus nucleoprotein is recognized by cytotoxic T lymphocytes with high functional avidity Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity.The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro.Variation at extra-epitopic amino acid residues influences suppression of influenza virus replication by M158-66 epitope-specific CD8+ T lymphocytes.Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine.

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P2860

Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes

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2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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JVI.79.17.11239-11246.2005

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Journal of Virology

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Functional constraints of infl ...... e from cytotoxic T lymphocytes

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Berkhoff EG

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Fouchier RA

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Geelhoed-Mieras MM

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Osterhaus AD

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Rimmelzwaan GF

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P2860

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells.

A structural basis for immunodominant human T cell receptor recognition

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

A DNA transfection system for generation of influenza A virus from eight plasmids

Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice.

Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.

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