Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.
about
A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophreniaParkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expressionSNCA variant associated with Parkinson disease and plasma alpha-synuclein level.Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.The genetic background of Parkinson's disease: current progress and future prospects.Association analysis of PARP1 polymorphisms with Parkinson's disease.Genetic Variants of SNCA Are Associated with Susceptibility to Parkinson's Disease but Not Amyotrophic Lateral Sclerosis or Multiple System Atrophy in a Chinese Population.Aspects of innate immunity and Parkinson's disease.SNCA and MAPT genes: Independent and joint effects in Parkinson disease in the Italian populationTranscriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1.Alpha-synuclein and familial Parkinson's diseaseThe Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites.GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in VivoUp-regulation of SNCA gene expression: implications to synucleinopathiesGenetics of Parkinson disease.Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain.Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cellsRegion-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.Molecular pathogenesis of Parkinson disease: insights from genetic studies.Adapter proteins and promoter regulation of the angiotensin AT2 receptor--implications for cardiac pathophysiology.Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1.Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies.α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.Gene regulation as a potential avenue for the treatment of neurodegenerative disorders.The role of β-adrenergic blockers in Parkinson's disease: possible genetic and cell-signaling mechanisms.Advances in the genetics of Parkinson disease.Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing.Structural variants in SNCA gene and the implication to synucleinopathies.Regulation of HFE expression by poly(ADP-ribose) polymerase-1 (PARP1) through an inverted repeat DNA sequence in the distal promoter.Deregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T.Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168.Accurate prediction of a minimal region around a genetic association signal that contains the causal variant.Discovery of functional non-coding conserved regions in the α-synuclein gene locus.The neuroprotective effect of nicotine in Parkinson's disease models is associated with inhibiting PARP-1 and caspase-3 cleavage.
P2860
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P2860
Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@ast
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@en
type
label
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@ast
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@en
prefLabel
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@ast
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@en
P2093
P2860
P356
P1476
Regulation of alpha-synuclein ...... ite upstream of the SNCA gene.
@en
P2093
Jeffrey A Kowalak
Mark E Smulson
Ornit Chiba-Falek
Robert L Nussbaum
P2860
P304
P356
10.1086/428655
P407
P577
2005-01-25T00:00:00Z