beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
about
In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human isletsMutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans.Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in miceDetermining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach.Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitusLow frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.Mutations in the coding regions of the hepatocyte nuclear factor 4 alpha in Iranian families with maturity onset diabetes of the youngPolygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.Defining and characterizing the progression of type 2 diabetes.Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes.Joint identification of genetic variants for physical activity in Korean population.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients.Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure.Pharmacogenetics in clinical practice: considerations for testing.Monogenic forms of obesity and diabetes mellitus.Genetics of type 2 diabetes and insulin resistance: knowledge from human studies.Pancreatic Duodenal Homeobox (PDX-1) in health and disease.SEL1L regulates adhesion, proliferation and secretion of insulin by affecting integrin signaling.Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus.Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.Acquired non-type 1 diabetes in childhood: subtypes, diagnosis, and management.Clinical features and treatment of maturity onset diabetes of the young (MODY).Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young.Defining the genetic aetiology of monogenic diabetes can improve treatment.Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered?Genetics of type 2 diabetes mellitus and obesity--a review.Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young.Identification of a novel beta-cell glucokinase (GCK) promoter mutation (-71G>C) that modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycemia in humansRNA processing and mRNA surveillance in monogenic diabetes.Mutations in the SLC30A8 gene are not a major cause of MODY or other forms of early-onset, autosomal dominant type 2 diabetes.Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications.Identification and functional analysis of c.422_423InsT, a novel mutation of the HNF1A gene in a patient with diabetesGenetic polymorphisms in diabetes: influence on therapy with oral antidiabetics.Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway.A Single Nucleotide Variant in HNF-1β is Associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family.
P2860
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P2860
beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
beta-cell genes and diabetes: ...... ions in transcription factors.
@ast
beta-cell genes and diabetes: ...... ions in transcription factors.
@en
type
label
beta-cell genes and diabetes: ...... ions in transcription factors.
@ast
beta-cell genes and diabetes: ...... ions in transcription factors.
@en
prefLabel
beta-cell genes and diabetes: ...... ions in transcription factors.
@ast
beta-cell genes and diabetes: ...... ions in transcription factors.
@en
P2093
P1433
P1476
beta-cell genes and diabetes: ...... ions in transcription factors.
@en
P2093
Frayling TM
Hannemann M
Hattersley AT
P304
P356
10.2337/DIABETES.50.2007.S94
P407
P478
50 Suppl 1
P577
2001-02-01T00:00:00Z