Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
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Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionNicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.Metabolic syndrome and the role of dietary lifestyles in Alzheimer's diseaseA ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisalMetabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and TreatmentInsulin: an emerging treatment for Alzheimer's disease dementia?Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brainTherapeutic targets of brain insulin resistance in sporadic Alzheimer's diseaseDiabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stressRoles of vascular and metabolic components in cognitive dysfunction of Alzheimer disease: short- and long-term modification by non-genetic risk factorsAberrant insulin signaling in Alzheimer's disease: current knowledgeAPP intracellular domain-WAVE1 pathway reduces amyloid-β production.Diabetes mellitus and cognitive impairmentsBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseA functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationCognitive dysfunction and diabetes mellitusEffect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trialSex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease.Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial.Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesiaAcute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoInsulin, cognition, and dementiaInsulin action in brain regulates systemic metabolism and brain function.Type 2 diabetes mellitus, cognition and brain in aging: A brief reviewEffects of insulin resistance on white matter microstructure in middle-aged and older adults.Is Alzheimer's disease a systemic disease?Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts.Brain aging and AD-like pathology in streptozotocin-induced diabetic rats.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's diseaseLong-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse.Insulin resistance and gray matter volume in neurodegenerative disease.Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review.Insulin resistance in Alzheimer's disease.Alterations in function and expression of ABC transporters at blood-brain barrier under diabetes and the clinical significances.Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?Insulin signaling in sporadic Alzheimer's diseaseSex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease.Caloric intake, dietary lifestyles, macronutrient composition, and alzheimer' disease dementiaGenetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.
P2860
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P2860
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@ast
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@en
type
label
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@ast
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@en
prefLabel
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@ast
Stimulation of beta-amyloid pr ...... ated protein kinase signaling.
@en
P2093
P1476
Stimulation of beta-amyloid pr ...... vated protein kinase signaling
@en
P2093
P304
P356
10.1523/JNEUROSCI.21-08-02561.2001
P407
P577
2001-04-01T00:00:00Z