Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
about
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectivesPulmonary fibrosis in response to environmental cues and molecular targets involved in its pathogenesisLipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA.Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.Evaluation of a method for nitrotyrosine site identification and relative quantitation using a stable isotope-labeled nitrated spike-in standard and high resolution fourier transform MS and MS/MS analysisDeficiency of α7 nicotinic acetylcholine receptor attenuates bleomycin-induced lung fibrosis in miceMaintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors.Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation.Recent advances in arginine metabolism: roles and regulation of the arginases.Protein S-nitrosylation in health and disease: a current perspective.Modulation of NF-κB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice.DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma.Nitric oxide metabolism in asthma pathophysiology.Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion.The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act.Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Increased mitochondrial arginine metabolism supports bioenergetics in asthma.Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorderProteomic approaches to evaluate protein S-nitrosylation in disease.Modulation of Asthma Pathogenesis by Nitric Oxide Pathways and Therapeutic OpportunitiesArginine metabolic endotypes related to asthma severity.Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsivenessArginase and arginine dysregulation in asthma.Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.Transflammation: Innate immune signaling in nuclear reprogramming.Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.Arginase-2 mediates renal ischemia-reperfusion injury.Arginase inhibitor attenuates pulmonary artery hypertension induced by hypoxia.Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
P2860
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P2860
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Inhibition of arginase activit ...... lation and tyrosine nitration.
@ast
Inhibition of arginase activit ...... lation and tyrosine nitration.
@en
type
label
Inhibition of arginase activit ...... lation and tyrosine nitration.
@ast
Inhibition of arginase activit ...... lation and tyrosine nitration.
@en
prefLabel
Inhibition of arginase activit ...... lation and tyrosine nitration.
@ast
Inhibition of arginase activit ...... lation and tyrosine nitration.
@en
P2093
P2860
P50
P1476
Inhibition of arginase activit ...... lation and tyrosine nitration.
@en
P2093
Albert van der Vliet
Anniek Lampert
Charles G Irvin
David Kasahara
Jessica Reiss
Karina Ckless
Lennart K A Lundblad
Ryan Norton
P2860
P304
P356
10.4049/JIMMUNOL.181.6.4255
P407
P577
2008-09-01T00:00:00Z