Conditional mutations in gamma-tubulin reveal its involvement in chromosome segregation and cytokinesis.
about
Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleationgamma-tubulin plays an essential role in the coordination of mitotic events.The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbs the establishment and maintenance of cell polarity in preimplantation rat embryos.NME7 is a functional component of the γ-tubulin ring complexEffects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast.A fourth component of the fission yeast gamma-tubulin complex, Alp16, is required for cytoplasmic microtubule integrity and becomes indispensable when gamma-tubulin function is compromisedCentrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitinationγ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis.Polar expeditions--provisioning the centrosome for mitosis.γ-Tubulin complexes in microtubule nucleation and beyond.Tetrahymena thermophila contains a conventional gamma-tubulin that is differentially required for the maintenance of different microtubule-organizing centers.Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila.Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6)Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization.GTP regulates the microtubule nucleation activity of γ-tubulin.Overexpression of truncated gamma-tubulins disrupts mitotic aster formation in Xenopus oocyte extractsFunctional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe.Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability.Molecular insight into γ-γ tubulin lateral interactions within the γ-tubulin ring complex (γ-TuRC).Gamma-tubulin is essential for acentrosomal microtubule nucleation and coordination of late mitotic events in Arabidopsis.Plant gamma-tubulin interacts with alphabeta-tubulin dimers and forms membrane-associated complexes.Gamma-tubulin is essential for microtubule organization and development in Arabidopsis.Modulation of Alp4 function in Schizosaccharomyces pombe induces novel phenotypes that imply distinct functions for nuclear and cytoplasmic gamma-tubulin complexes.Tubulinopathies continued: refining the phenotypic spectrum associated with variants in TUBG1γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential
P2860
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P2860
Conditional mutations in gamma-tubulin reveal its involvement in chromosome segregation and cytokinesis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Conditional mutations in gamma ...... e segregation and cytokinesis.
@ast
Conditional mutations in gamma ...... e segregation and cytokinesis.
@en
type
label
Conditional mutations in gamma ...... e segregation and cytokinesis.
@ast
Conditional mutations in gamma ...... e segregation and cytokinesis.
@en
prefLabel
Conditional mutations in gamma ...... e segregation and cytokinesis.
@ast
Conditional mutations in gamma ...... e segregation and cytokinesis.
@en
P2093
P2860
P356
P1476
Conditional mutations in gamma ...... e segregation and cytokinesis.
@en
P2093
A H Corbett
T W Hendrickson
P2860
P304
P356
10.1091/MBC.12.8.2469
P577
2001-08-01T00:00:00Z