DARPins and other repeat protein scaffolds: advances in engineering and applications.
about
New viruses for cancer therapy: meeting clinical needsRecent advances in engineering polyvalent biological interactionsSH3 domains come of ageConformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptorsStructural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein librariesDevelopment of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adaptersStructure-based optimization of designed Armadillo-repeat proteinsDesign, construction, and characterization of a second-generation DARPin library with reduced hydrophobicitySelection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep)C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffoldN-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactionsLigand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomesDiscrete kinetic models from funneled energy landscape simulationsAmyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer diseaseDirected Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase.Isolation of monobodies that bind specifically to the SH3 domain of the Fyn tyrosine protein kinase.Novel ubiquitin-derived high affinity binding proteins with tumor targeting properties.Crystal structures of designed armadillo repeat proteins: implications of construct design and crystallization conditions on overall structure.Rational design of α-helical tandem repeat proteins with closed architecturesAmphipol-mediated screening of molecular orthoses specific for membrane protein targets.Dissecting the critical factors for thermodynamic stability of modular proteins using molecular modeling approach.A high-affinity protein binder that blocks the IL-6/STAT3 signaling pathway effectively suppresses non-small cell lung cancer.Consensus design of a NOD receptor leucine rich repeat domain with binding affinity for a muramyl dipeptide, a bacterial cell wall fragmentKnowledge-based design of a biosensor to quantify localized ERK activation in living cells.Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesFoundations for the design and implementation of synthetic genetic circuits.Bio-inspired voltage-dependent calcium channel blockersOptimization of designed armadillo repeat proteins by molecular dynamics simulations and NMR spectroscopy.Detection of biomarkers using recombinant antibodies coupled to nanostructured platformsPeptide aptamers: development and applications.Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry.Computational design of a leucine-rich repeat protein with a predefined geometryNanobody mediated crystallization of an archeal mechanosensitive channel.Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging.Directed evolution of three-finger toxin to produce serine protease inhibitors.Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana.Scalable high throughput selection from phage-displayed synthetic antibody libraries.Specific GFP-binding artificial proteins (αRep): a new tool for in vitro to live cell applications
P2860
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P2860
DARPins and other repeat protein scaffolds: advances in engineering and applications.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@ast
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@en
type
label
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@ast
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@en
prefLabel
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@ast
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@en
P1476
DARPins and other repeat protein scaffolds: advances in engineering and applications.
@en
P2093
Ykelien L Boersma
P304
P356
10.1016/J.COPBIO.2011.06.004
P577
2011-06-27T00:00:00Z