Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
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Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interactionKras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lungStructure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitorThe Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyLinking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD)Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interactionThe FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interactionLoss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15)A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteinsF-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagyCommon and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse modelDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.Roles of F-box proteins in cancerRegulation of CDK4Status of the Parkinson's disease gene family expression in non-small-cell lung cancer.Quantification of ortholog losses in insects and vertebrates.Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traitsUbiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsGenome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.CDK6 binds and promotes the degradation of the EYA2 proteinGsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27Recent advances in SCF ubiquitin ligase complex: Clinical implicationsDefective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression.FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.miR-449a and CDK6 in gastric carcinoma.Ubiquitin and Parkinson's disease through the looking glass of genetics.Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in miceThe F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 proteinCharacterization of the porcine FBX07 gene: the first step towards generation of a pig model for Parkinsonian pyramidal syndrome.
P2860
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P2860
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@ast
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@en
type
label
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@ast
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@en
prefLabel
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@ast
Transforming activity of Fbxo7 ...... h regulation of cyclin D/cdk6.
@en
P2093
P2860
P356
P1433
P1476
Transforming activity of Fbxo7 ...... gh regulation of cyclin D/cdk6
@en
P2093
Chris Boshoff
Hongtao Ye
Juan M Funes
Laura Galinanes-Garcia
Neil McDonald
Phillip Knowles
P2860
P304
P356
10.1038/SJ.EMBOJ.7600775
P407
P577
2005-08-11T00:00:00Z