Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery.
about
Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).Review of Platensimycin and Platencin: Inhibitors of β-Ketoacyl-acyl Carrier Protein (ACP) Synthase III (FabH)Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo ActivityMode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI InhibitorStaphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo EssentialityVibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductaseTriclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase3-oxoacyl-ACP reductase from Schistosoma japonicum: integrated in silico-in vitro strategy for discovering antischistosomal lead compoundsIdentification of antimicrobial targets using a comprehensive genomic approach.Challenges of antibacterial discoveryPurification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureusDefining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus.Discovery of a novel and potent class of FabI-directed antibacterial agentsThe fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pHFrom microbial gene essentiality to novel antimicrobial drug targetsNovel targets for the future development of antibacterial agents.The MUT056399 inhibitor of FabI is a new antistaphylococcal compound.Crystallization and preliminary X-ray crystallographic studies of a new class of enoyl-(acyl-carrier protein) reductase, FabV, from Vibrio fischeriType II polyketide synthases: gaining a deeper insight into enzymatic teamwork.Using genomics to develop novel antibacterial therapeutics.Platensimycin and platencin: promising antibiotics for future application in human medicine.Studies of Staphylococcus aureus FabI inhibitors: fragment-based approach based on holographic structure-activity relationship analyses.Evaluation of antibacterial and antibiofilm mechanisms by usnic acid against methicillin-resistant Staphylococcus aureus.Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents.Bacterial fatty acid metabolism in modern antibiotic discovery.Target-based molecular modeling strategies for schistosomiasis drug discovery.Docking and molecular dynamics studies on triclosan derivatives binding to FabI.Exogenous fatty acid metabolism in bacteria.Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs.Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery.THE BIOFILM CONCEPT: CONSEQUENCES FOR FUTURE PROPHYLAXIS OF ORAL DISEASES?Substrate recognition by β-ketoacyl-ACP synthases.Dissemination of Novel Antimicrobial Resistance Mechanisms through the Insertion Sequence Mediated Spread of Metabolic Genes.Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis.Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids.Design, Synthesis, SAR and Molecular Modeling Studies of Novel Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives as Highly Potent Antimicrobial Agents.Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity.Characterization of the Adaptive Amoxicillin Resistance of Lactobacillus casei Zhang by Proteomic Analysis.Current Awareness on Comparative and Functional Genomics
P2860
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P2860
Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@ast
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@en
type
label
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@ast
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@en
prefLabel
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@ast
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@en
P2093
P1433
P1476
Bacterial fatty-acid biosynthe ...... antibacterial drug discovery.
@en
P2093
D J. Holmes
D J. Payne
J T. Lonsdale
P V. Warren
P304
P356
10.1016/S1359-6446(01)01774-3
P577
2001-05-01T00:00:00Z